Structural Properties of Phenylalanine-Based Dimers Revealed Using IR Action Spectroscopy

被引:4
作者
Stroganova, Iuliia [1 ,2 ]
Bakels, Sjors [1 ,2 ]
Rijs, Anouk M. [1 ]
机构
[1] Vrije Univ Amsterdam, AIMMS Amsterdam Inst Mol & Life Sci, Div BioAnalyt Chem, De Boelelaan 1108, NL-1081 HV Amsterdam, Netherlands
[2] Radboud Univ Nijmegen, Inst Mol & Mat, FELIX Lab, Toernooiveld 7, NL-6525 ED Nijmegen, Netherlands
来源
MOLECULES | 2022年 / 27卷 / 07期
基金
荷兰研究理事会;
关键词
infrared spectroscopy; self-assembly; molecular beam; peptide aggregates; DOUBLE-RESONANCE SPECTROSCOPY; GAS-PHASE; PEPTIDE NANOTUBES; DIPHENYLALANINE; MODEL; INSIGHTS; NANOSTRUCTURES; AGGREGATION; MICROTUBES; TRANSITION;
D O I
10.3390/molecules27072367
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Peptide segments with phenylalanine residues are commonly found in proteins that are related to neurodegenerative diseases. However, the self-assembly of phenylalanine-based peptides can be also functional. Peptides containing phenylalanine residues with different side caps, composition, and chemical alteration can form different types of nanostructures that find many applications in technology and medicine. Various studies have been performed in order to explain the remarkable stability of the resulting nanostructures. Here, we study the early stages of self-assembly of two phenylalanine derived peptides in the gas phase using IR action spectroscopy. Our focus lies on the identification of the key intra- and intermolecular interactions that govern the formation of the dimers. The far-IR region allowed us to distinguish between structural families and to assign the 2-(2-amino-2-phenylacetamido)-2-phenylacetic acid (PhgPhg) dimer to a very symmetric structure with two intermolecular hydrogen bonds and its aromatic rings folded away from the backbone. By comparison with the phenylalanine-based peptide cyclic L-phenylalanyl-L-phenylalanine (cyclo-FF), we found that the linear FF dimer likely adopts a less ordered structure. However, when one more phenylalanine residue is added (FFF), a more structurally organized dimer is formed with several intermolecular hydrogen bonds.
引用
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页数:18
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