Epstein-Barr virus infection mechanisms

被引：20

作者：

Chesnokova, Liudmila S.

Hutt-Fletcher, Lindsey M. ^{[1
,2
]}

机构：

[1] Louisiana State Univ, Hlth Sci Ctr, Ctr Mol Tumor Virol, Dept Microbiol & Immunol, Shreveport, LA 71130 USA

[2] Louisiana State Univ, Hlth Sci Ctr, Feist Weiller Canc Ctr, Shreveport, LA 71130 USA

来源：

CHINESE JOURNAL OF CANCER | 2014年 / 33卷 / 11期

关键词：

Glycoproteins; complement receptor type 2; HLA class II; integrins; entry; ORAL EPITHELIAL-CELLS; B-CELLS; HERPESVIRUS ENTRY; CONFORMATIONAL-CHANGE; GLYCOPROTEINS GHGL; CRYSTAL-STRUCTURE; MEMBRANE-FUSION; BINDING; GH/GL; COMPLEX;

D O I：

10.5732/cjc.014.10168

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epstein-Barr virus (EBV) infection occurs by distinct mechanisms across different cell types. EBV infection of B cells in vitro minimally requires 5 viral glycoproteins and 2 cellular proteins. By contrast, infection of epithelial cells requires a minimum of 3 viral glycoproteins, which are capable of interacting with one or more of 3 different cellular proteins. The full complement of proteins involved in entry into all cell types capable of being infected in vivo is unknown. This review discusses the events that occur when the virus is delivered into the cytoplasm of a cell, the players known to be involved in these events, and the ways in which these players are thought to function.

引用

页码：545 / 548

页数：4

共 37 条

[21] Mapping the N-Terminal Residues of Epstein-Barr Virus gp42 That Bind gH/gL by Using Fluorescence Polarization and Cell-Based Fusion Assays [J].

Liu, Fengling ;

Marquardt, Gaby ;

Kirschner, Austin N. ;

Longnecker, Richard ;

Jardetzky, Theodore S. .

JOURNAL OF VIROLOGY, 2010, 84 (19) :10375-10385

[22] Crystal structure of the Epstein-Barr virus (EBV) glycoprotein H/glycoprotein L (gH/gL) complex [J].

Matsuura, Hisae ;

Kirschner, Austin N. ;

Longnecker, Richard ;

Jardetzky, Theodore S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (52) :22641-22646

[23] EPSTEIN-BARR-VIRUS ENTERS B-CELLS AND EPITHELIAL-CELLS BY DIFFERENT ROUTES [J].

MILLER, N ;

HUTTFLETCHER, LM .

JOURNAL OF VIROLOGY, 1992, 66 (06) :3409-3414

[24] Structure of the Epstein-Barr virus gp42 protein bound to the MHC class II receptor HLA-DR1 [J].

Mullen, MM ;

Haan, KM ;

Longnecker, R ;

Jardetzky, TS .

MOLECULAR CELL, 2002, 9 (02) :375-385

[25] Epstein-Barr virus-induced B-cell transformation: quantitating events from virus binding to cell outgrowth [J].

Shannon-Lowe, C ;

Baldwin, G ;

Feederle, R ;

Bell, A ;

Rickinson, A ;

Delecluse, HJ .

JOURNAL OF GENERAL VIROLOGY, 2005, 86 :3009-3019

[26] Resting B cells as a transfer vehicle for Epstein-Barr virus infection of epithelial cells [J].

Shannon-Lowe, CD ;

Neuhierl, B ;

Baldwin, G ;

Rickinson, AB ;

Delecluset, HJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (18) :7065-7070

[27] Mutational analyses of Epstein-Barr virus glycoprotein 42 reveal functional domains not involved in receptor binding but required for membrane fusion [J].

Silva, AL ;

Omerovic, J ;

Jardetzky, TS ;

Longnecker, R .

JOURNAL OF VIROLOGY, 2004, 78 (11) :5946-5956

[28] Cleavage and Secretion of Epstein-Barr Virus Glycoprotein 42 Promote Membrane Fusion with B Lymphocytes [J].

Sorem, Jessica ;

Jardetzky, Theodore S. ;

Longnecker, Richard .

JOURNAL OF VIROLOGY, 2009, 83 (13) :6664-6672

[29] Herpesvirus entry: an update [J].

Spear, PG ;

Longnecker, R .

JOURNAL OF VIROLOGY, 2003, 77 (19) :10179-10185

[30] Stuck in the middle: structural insights into the role of the gH/gL heterodimer in herpesvirus entry [J].

Stampfer, Samuel D. ;

Heldwein, Ekaterina E. .

CURRENT OPINION IN VIROLOGY, 2013, 3 (01) :13-19

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