Liquid Biopsy in Diagnosis and Prognosis of High-Grade Gliomas; State-of-the-Art and Literature Review

被引：16

作者：

Bonosi, Lapo ^{[1
]}

Ferini, Gianluca ^{[2
]}

Giammalva, Giuseppe Roberto ^{[1
]}

Benigno, Umberto Emanuele ^{[1
]}

Porzio, Massimiliano ^{[1
]}

Giovannini, Evier Andrea ^{[1
]}

Musso, Sofia ^{[1
]}

Gerardi, Rosa Maria ^{[1
]}

Brunasso, Lara ^{[1
]}

Costanzo, Roberta ^{[1
]}

Paolini, Federica ^{[1
]}

Graziano, Francesca ^{[3
]}

Scalia, Gianluca ^{[3
]}

Umana, Giuseppe Emmanuele ^{[4
]}

Di Bonaventura, Rina ^{[5
]}

Sturiale, Carmelo Lucio ^{[5
]}

Iacopino, Domenico Gerardo ^{[1
]}

Maugeri, Rosario ^{[1
]}

机构：

[1] Univ Palermo, Post Grad Residency Program Neurol Surg, Dept Biomed Neurosci & Adv Diagnost, Neurosurg Clin,AOUP Paolo Giaccone,Sch Med, I-90127 Palermo, Italy

[2] REM Radioterapia Srl, Dept Radiat Oncol, I-95125 Catania, Italy

[3] Garibaldi Hosp, Unit Neurosurg, I-95124 Catania, Italy

[4] Cannizzaro Hosp, Trauma Ctr, Gamma Knife Ctr, Dept Neurosurg, I-95125 Catania, Italy

[5] Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli IRCCS, Dept Neurosurg, I-00168 Rome, Italy

来源：

LIFE-BASEL | 2022年 / 12卷 / 03期

关键词：

liquid biopsy; high-grade glioma; GBM; circulating tumor DNA; extracellular vesicles; miRNA; next-generation sequencing; CENTRAL-NERVOUS-SYSTEM; TUMOR DNA; EGFR; MICRORNA; CANCER;

D O I：

10.3390/life12030407

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Gliomas, particularly high-grade gliomas, represent the most common and aggressive tumors of the CNS and are still burdened by high mortality and a very poor prognosis, regardless of the type of therapy. Their diagnosis and monitoring rely on imaging techniques and direct biopsy of the pathological tissue; however, both procedures have inherent limitations. To address these limitations, liquid biopsies have been proposed in this field. They could represent an innovative tool that could help clinicians in the early diagnosis, monitoring, and prognosis of these tumors. Furthermore, the rapid development of next-generation sequencing (NGS) technologies has led to a significant reduction in sequencing cost, with improved accuracy, providing a molecular profile of cancer and leading to better survival results and less disease burden. This paper focuses on the current clinical application of liquid biopsy in the early diagnosis and prognosis of cancer, introduces NGS-related methods, reviews recent progress, and summarizes challenges and future perspectives.

引用

页数：14

共 59 条

[51] Emerging role of miRNAs as liquid biopsy markers for prediction of glioblastoma multiforme prognosis [J].