Astrocytosis in parkinsonism: considering tripartite striatal synapses in physiopathology?

被引：42

作者：

Charron, Giselle ^{[1
,2
]}

Doudnikoff, Evelyne ^{[1
,2
]}

Canron, Marie-Helene ^{[1
,2
]}

Li, Qin ^{[3
,4
]}

Vega, Celine ^{[2
,5
]}

Marais, Sebastien ^{[6
,7
,8
]}

Baufreton, Jerome ^{[1
,2
]}

Vital, Anne ^{[1
,2
]}

Oliet, Stephane H. R. ^{[9
]}

Bezard, Erwan ^{[1
,2
,3
,4
]}

机构：

[1] Univ Bordeaux, Inst Malad Neurodegenerat, UMR 5293, Bordeaux, France

[2] Inst Malad Neurodegenerat, CNRS, UMR 5293, F-33076 Bordeaux, France

[3] Chinese Acad Med Sci, Inst Lab Anim Sci, Beijing 100730, Peoples R China

[4] Peking Union Med Coll, Beijing 100021, Peoples R China

[5] Univ Paris 06, UFR Sci Vie, Paris, France

[6] Univ Bordeaux, Bordeaux Imaging Ctr, UMS 3420, Bordeaux, France

[7] CNRS, Bordeaux Imaging Ctr, UMS 3420, Bordeaux, France

[8] INSERM, Bordeaux Imaging Ctr, US 004, Bordeaux, France

[9] Inst Natl Sante & Rech Med, Neuroctr Magendie, U862, Bordeaux, France

来源：

FRONTIERS IN AGING NEUROSCIENCE | 2014年 / 6卷

关键词：

immunohistochemistry; medium spiny neuron; astrocyte; dopamine; mouse; rat; monkey; human; GAP-JUNCTIONS; DOPAMINE-RECEPTOR; GLUTAMATE TRANSPORTERS; ALPHA-SYNUCLEIN; SPINE DENSITY; EXPRESSION; NEURONS; PLASTICITY; BRAIN; NETWORKS;

D O I：

10.3389/fnagi.2014.00258

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The current concept of basal ganglia organization and function in physiological and pathophysiological conditions excludes the most numerous cells in the brain, i.e., the astrocytes, present with a ratio of 10:1 neuron. Their role in neurodegenerative condition such as Parkinson's disease (PD) remains to be elucidated. Before embarking into physiological investigations of the yet-to-be-identified "tripartite" synapses in the basal ganglia in general and the striatum in particular, we therefore characterized anatomically the PD-related modifications in astrocytic morphology, the changes in astrocytic network connections and the consequences on the spatial relationship between astrocytic processes and asymmetric synapses in normal and PD-like conditions in experimental and human PD. Our results unravel a dramatic regulation of striatal astrocytosis supporting the hypothesis of a key role in (dys) regulating corticostriatal transmission. Astrocytes and their various properties might thus represent a therapeutic target in PD.

引用

页数：12

共 69 条

[1] Astrocytic connexin distributions and rapid, extensive dye transfer via gap junctions in the inferior colliculus:: Implications for [14C]glucose metabolite trafficking [J].