Active Accumulation of Spherical Analytes on Plasmonic Hot Spots of Double-Bent Au Strip Arrays by Multiple Dip-Coating
被引:7
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Lee, Jinhyung
[1
,2
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You, Eun-Ah
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机构:
Korea Res Inst Stand & Sci, Ctr Nanobio Measurement, Daejeon 34113, South KoreaKorea Res Inst Stand & Sci, Ctr Nanobio Measurement, Daejeon 34113, South Korea
You, Eun-Ah
[1
]
Hwang, Do Won
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Seoul Natl Univ Hosp, Dept Nucl Med, Seoul 03080, South KoreaKorea Res Inst Stand & Sci, Ctr Nanobio Measurement, Daejeon 34113, South Korea
Hwang, Do Won
[3
]
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Kang, Shinill
[2
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Wi, Jung-Sub
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Korea Res Inst Stand & Sci, Ctr Nanobio Measurement, Daejeon 34113, South KoreaKorea Res Inst Stand & Sci, Ctr Nanobio Measurement, Daejeon 34113, South Korea
Wi, Jung-Sub
[1
]
机构:
[1] Korea Res Inst Stand & Sci, Ctr Nanobio Measurement, Daejeon 34113, South Korea
[2] Yonsei Univ, Sch Mech Engn, Seoul 03722, South Korea
[3] Seoul Natl Univ Hosp, Dept Nucl Med, Seoul 03080, South Korea
To achieve sensitive plasmonic biosensors, it is essential to develop an efficient method for concentrating analytes in hot spots, as well as to develop plasmonic nanostructures for concentrating light. In this study, target analytes were delivered to the surface of double-bent Au strip arrays by a multiple dip-coating method; they were self-aligned in the valleys between neighboring Au strips by capillary forces. As the valleys not only accommodate target analytes but also host strong electromagnetic fields due to the interaction between adjacent strips, sensitive measurement of target analytes was possible by monitoring changes in the wavelength of a localized surface plasmon resonance. Using the proposed plasmonic sensor and target delivery method, the adsorption and saturation of polystyrene beads 100 nm in size on the sensor surface were monitored by the shift of the resonance wavelength. In addition, the pH-dependent stability of exosomes accumulated on the sensor surface was successfully monitored by changing the pH from 7.4 to 4.0.