The epigenetically-regulated miR-34a targeting c-SRC suppresses RAF/MEK/ERK signaling pathway in K-562 cells

被引：10

作者：

Yang, Yang ^{[1
]}

Ding, Li ^{[1
]}

Guo, Zi-Kuan ^{[2
]}

Zheng, Xiao-Li ^{[1
]}

Wang, Li-Sheng ^{[2
]}

Sun, Hui-Yan ^{[2
]}

Jin, Zhan-Guo ^{[3
]}

Wang, Heng-Xiang ^{[1
]}

机构：

[1] Chinese PLA Air Force Gen Hosp, Dept Hematol, 30 Fucheng Rd, Beijing 100042, Peoples R China

[2] Chinese PLA Acad Mil Med Sci, Beijing Inst Radiat Med, Beijing 100850, Peoples R China

[3] Chinese PLA Air Force Gen Hosp, Aerosp Balance Med Ctr, Beijing 100042, Peoples R China

来源：

LEUKEMIA RESEARCH | 2017年 / 55卷

基金：

中国国家自然科学基金;

关键词：

miR-34a; c-SRC; Methylation; Epigenetic; LEUKEMIA; CANCER;

D O I：

10.1016/j.leukres.2017.01.020

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Previous reports show that miR-34a suppressed K-562 cell proliferation and contributed to megakaryocytic differentiation of K-562 cells. Here, we reported that miR-34a, a tumor suppressor gene, is down-regulated in the K-562 cells and chronic myeloid leukemia (CML) patients due to aberrant DNA hypermethylation. c-SRC is a target of miR-34a. Restoring miR-34a expression resulted in down regulation of c-SRC and phosphorylated (Tyr416) c-SRC protein in K-562 cells, which consequently triggered suppression of the RAF/MEK/ERK signaling pathway to decrease cell proliferation. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：91 / 96

页数：6

共 9 条

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