Brain metabolomics in rats after administration of ketamine

被引：56
作者：
Wen, Congcong [1 ]
Zhang, Meiling [2 ,3 ]
Zhang, Yuan [2 ,3 ]
Sun, Fa [2 ]
Ma, Jianshe [2 ,3 ]
Hu, Lufeng [4 ]
Lin, Guanyang [4 ]
Wang, Xianqin [2 ,3 ]
机构：
[1] Wenzhou Med Univ, Lab Anim Ctr, Wenzhou 325035, Peoples R China
[2] Wenzhou Med Univ, Analyt & Testing Ctr, Wenzhou 325035, Peoples R China
[3] Wenzhou Med Univ, Forens Ctr, Forens Toxicol Lab, Wenzhou 325035, Peoples R China
[4] Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou 325000, Peoples R China
来源：
BIOMEDICAL CHROMATOGRAPHY | 2016年 / 30卷 / 01期
关键词：
metabolomics; GC; MS; ketamine; abuse; MASS-SPECTROMETRY; DRUG-USE; ABUSE; IDENTIFICATION;
D O I：
10.1002/bmc.3518
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
In this study, we developed a brain metabolomic method, based on gas chromatography-mass spectrometry (GC/MS), to evaluate the effect of ketamine on rats. Pattern recognition analysis, including both principal component analysis and partial least squares-discriminate analysis revealed that ketamine induced metabolic perturbations. Compared with the control group, the levels of glycerol, uridine, cholesterol in rat brain of the ketamine group (50 mg/kg, 14 days) decreased, while the urea levels increased. Our results indicate that metabolomic methods based on GC/MS may be useful to elucidate ketamine abuse through the exploration of biomarkers. Copyright (c) 2015 John Wiley & Sons, Ltd.
引用
收藏
页码：81 / 84
页数：4
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