Antiviral Triterpenes from the Twigs and Leaves of Lyonia ovalifolia

被引：30

作者：

Lv, Xiao-Jing ^{[1
,2
]}

Li, Yong ^{[1
,2
]}

Ma, Shuang-Gang ^{[1
,2
]}

Qu, Jing ^{[1
,2
]}

Liu, Yun-Bao ^{[1
,2
]}

Li, Yu-Huan ^{[2
,3
]}

Zhang, Dan ^{[1
,2
]}

Li, Li ^{[1
,2
]}

Yu, Shi-Shan ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

[3] Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2016年 / 79卷 / 11期

基金：

中国国家自然科学基金;

关键词：

ELLIPTICA HAND-MAZZ; ABSOLUTE-CONFIGURATION; CYCLOARTANE; GLYCOSIDES; ROOTS; CONSTITUENTS; MO-2(OAC)(4); COMPLEXES; GLUCOSIDE; 1,2-DIOLS;

D O I：

10.1021/acs.jnatprod.6b00585

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Eleven new 9,10-seco-cycloartan triterpene glycosides (1-11), seven new lanostane triterpene glycosides (12-18), and two new ursane triterpenoids (19-20) were isolated from the twigs and leaves of Lyonia ovalifolia. The structures of these compounds were elucidated by extensive MS and NMR spectroscopic analysis. The absolute configuration of compound la (the aglycone of 1) was established by X-ray crystallography, and that of C-24 in compounds 2, 7, and 12 was established by Mo-2(OAc)(4)-induced electronic circular dichroism experiments. All compounds were evaluated for their antiviral [herpes simplex virus-1 (HSV-1); influenza A/95-359 (A/95-359), and Coxsackie B3 (CVB3)] activity. Compounds 1, la, 2a, 12a, 13, and 16 exhibited potent activity against HSV-1, with IC50 values from 2.1 to 14.3 mu M, while compounds 1a, 2a, 12a, 13, and 12-12a exhibited potent activity against A/95-359, with IC50 values from 2.1 to 11.1 mu M. In turn, compounds 1, la, 2a, 12a, and 13 exhibited potent activity against CVB3, with IC50 values from 2.1 to 11.1 mu M.

引用

页码：2824 / 2837

页数：14

共 29 条

[1] 9,10-seco-9,19-cyclolanostane arabinosides from the roots of Actaea podocarpa [J].