Low expression of insulin-like growth factor binding protein 7 associated with poor prognosis in human glioma

被引：12
作者：
Tian, Xiangyang [1 ]
Zhang, Ling [2 ]
Sun, Laiguang [1 ]
Xue, Yihong [1 ]
Xie, Shuang [3 ]
机构：
[1] Xinxiang Cent Hosp, Dept Neurosurg, Xinxiang 453000, Henan, Peoples R China
[2] Xinxiang Cent Hosp, Med Record Lib, Xinxiang 453000, Henan, Peoples R China
[3] Peoples Liberat Army, Hosp 786, Dept Neurosurg, Nanyang, Henan, Peoples R China
来源：
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2014年 / 42卷 / 03期
关键词：
Insulin-like growth factor binding protein 7; glioma; human; prognosis; LUNG-CANCER; MELANOMA GROWTH; CELL-LINES; IGFBP7; APOPTOSIS; METHYLATION; PROGRESSION; SENESCENCE; INDUCTION; BLOCKS;
D O I：
10.1177/0300060513503926
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Objectives: To investigate insulin-like growth factor binding protein 7 (IGFBP7) mRNA levels in human glioma and normal brain tissue, and to determine their clinical significance. Methods: In this retrospective study, IGFBP7 mRNA was quantified by real-time reverse transcription-polymerase chain reaction in brain tissue samples from patients with glioma and normal control subjects. Kaplan-Meier and Cox proportional hazards analyses were performed to determine any clinical and prognostic associations. Results: IGFBP7 mRNA levels were significantly lower in glioma tissue (n = 120) than in normal brain tissue (n = 20). Low (i.e. below the median, 5.9) IGFBP7 mRNA levels were significantly associated with larger tumour size (>= 5 cm, compared with <5 cm, diameter). Patients with high (above median) IGFBP7 had longer overall survival than those with low IGFBP7. Tumour grade and IGFBP7 mRNA level were independent predictors of overall survival. Conclusions: IGFBP7 downregulation is associated with poor prognosis in glioma, and this molecule may represent both a prognostic marker and a potential therapeutic target.
引用
收藏
页码：651 / 658
页数：8
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