Iodine(III)-Mediated C-H Alkoxylation of Aniline Derivatives with Alcohols under Metal-Free Conditions

被引：20

作者：

Jiang, Qing ^{[1
]}

Wang, Jing-Yu ^{[1
]}

Guo, Cancheng ^{[1
]}

机构：

[1] Hunan Univ, Coll Chem & Chem Engn, Adv Catalyt Engn Res Ctr, Minist Educ, Changsha 410082, Hunan, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 79卷 / 18期

基金：

中国国家自然科学基金;

关键词：

CATALYZED ORTHO-ALKOXYLATION; HYPERVALENT IODINE REAGENTS; CARBON BOND FORMATION; C=N BRIDGING GROUP; MULTICOMPONENT REACTIONS; UNACTIVATED METHYLENE; OXIDATIVE CLEAVAGE; POLYVALENT IODINE; ACID-DERIVATIVES; C-13; NMR;

D O I：

10.1021/jo501601u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The development of a novel intermolecular oxidative C-H alkoxylation of aniline derivatives is described under metal-free conditions with high reaction rates at ambient temperature. In the presence of an I(III) oxidant, a range of aldehydes, anilines, and alcohol substrates undergo three-component coupling to produce synthetically useful alkoxyl-substituted N-arylimines. The preliminary mechanism investigations revealed that the transformation proceeds via imines as intermediates.

引用

页码：8768 / 8773

页数：6