4-Aryl-Substituted 2,5-Dimethoxyphenethylamines: Synthesis and Serotonin 5-HT2A Receptor Affinities

A series of novel ligands for the serotonin 5-HT2A/C receptor subtype bearing the 2-phenylethylamine pharmacophore was synthesized and assayed for its 5-HT2A receptor binding affinity. As the 4'-aryl-substituted 2-(2,5-dimethoxyphenyl)ethylamines were previously unknown, an initial series of twelve compounds was chosen to obtain initial insight into their structure-activity relationships. The 4'-aryl moiety was introduced in moderate-to-high yield by a Pd-catalyzed Suzuki reaction of twelve arylboronic acids with N-Boc-protected 2-(2,5-dimethoxy-4-iodophenyl)ethylamine (8). N-Boc Deprotection then afforded the novel 2-phenylethylamines 5a-5l. Additionally, biphenyl compound 6 lacking the 5'-MeO substituent was prepared, starting from 2-methoxy-4-hydroxybenzaldehyde. Except for 51, all of the compounds proved to be antagonists with generally low affinity at the rat 5-HT2A receptor. Substituents are generally not well tolerated on the 4'-aryl moiety, except in the 4 ''-position. Indeed, the relatively high affinity of the 4 ''-butyl-, 4 ''-phenyl-, and 4'-naphthyl-substituted compounds 5i, 5k, and 5e, respectively (K-i=32, 33, and 41nM, resp.), attests a rather remarkable tolerance for bulk in this location.