Thermally activated reversible shape switch of polymer particles

被引：72

作者：

Gong, Tao ^{[1
]}

Zhao, Kun ^{[1
]}

Wang, Wenxi ^{[1
]}

Chen, Hongmei ^{[1
]}

Wang, Lin ^{[1
]}

Zhou, Shaobing ^{[1
]}

机构：

[1] Southwest Jiaotong Univ, Sch Mat Sci & Engn, Minist Educ, Key Lab Adv Technol Mat, Chengdu 610031, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2014年 / 2卷 / 39期

基金：

高等学校博士学科点专项科研基金; 中国国家自然科学基金;

关键词：

EPSILON-CAPROLACTONE; MEMORY POLYMERS; CELLULAR INTERNALIZATION; MECHANICAL-PROPERTIES; TEMPERATURE MEMORY; DRUG CARRIERS; DESIGN; DELIVERY; NANOCOMPOSITES; COMPOSITES;

D O I：

10.1039/c4tb01155d

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

The particles that can reversibly switch shape in response to an environmental stimulus are preferable for controlling the performance of drug carriers. In this work, we present a facile strategy towards the design and fabrication of polymer particles that can reversibly switch their shape on the basis of a biocompatible and biodegradable polymer network containing well-defined six-arm poly(ethylene glycol)-poly(epsilon-caprolactone) (6A PEG-PCL). These polymer particles have a capacity of reversibly changing shape from spherical to elliptical either extracellularly or intracellularly with the cyclic heating and cooling between 43 degrees C and 0 degrees C under a stress-free condition via a reversible two-way shape memory effect (2W-SME) of a polymer matrix. This study of the shape-switching particles opens up exciting possibilities for engineering dynamically shape-switching drug delivery carriers to either avoid or promote phagocytosis.

引用

页码：6855 / 6866

页数：12

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