Repurposing of Human Kinase Inhibitors in Neglected Protozoan Diseases

被引:23
作者
Dichiara, Maria [1 ]
Marrazzo, Agostino [1 ]
Prezzavento, Orazio [1 ]
Collina, Simona [2 ]
Rescifina, Antonio [1 ]
Amata, Emanuele [1 ]
机构
[1] Univ Catania, Dept Drug Sci, Vle A Doria 6, I-95100 Catania, Italy
[2] Univ Pavia, Dept Drug Sci, Vle Taramelli 12, I-27100 Pavia, Italy
关键词
drug discovery; kinase inhibitors; neglected tropical diseases; parasites; repurposing; HUMAN AFRICAN TRYPANOSOMIASIS; BETA-CARBOLINE ALKALOIDS; DRUG DISCOVERY; PROTEIN-KINASE; CUTANEOUS LEISHMANIASIS; LEAD DISCOVERY; CHAGAS-DISEASE; IN-VITRO; BRUCEI; TARGET;
D O I
10.1002/cmdc.201700259
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Human African trypanosomiasis (HAT), Chagas disease, and leishmaniasis belong to a group of infectious diseases known as neglected tropical diseases and are induced by infection with protozoan parasites named trypanosomatids. Drugs in current use have several limitations, and therefore new candidate drugs are required. The majority of current therapeutic trypanosomatid targets are enzymes or cell-surface receptors. Among these, eukaryotic protein kinases are a major group of protein targets whose modulation may be beneficial for the treatment of neglected tropical protozoan diseases. This review summarizes the finding of new hit compounds for neglected tropical protozoan diseases, by repurposing known human kinase inhibitors on trypanosomatids. Kinase inhibitors are grouped by human kinase family and discussed according to the screening (target-based or phenotypic) reported for these compounds on trypanosomatids. This collection aims to provide insight into repurposed human kinase inhibitors and their importance in the development of new chemical entities with potential beneficial effects on the diseases caused by trypanosomatids.
引用
收藏
页码:1235 / 1253
页数:19
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