Two new terpenoids from the leaves of callicarpa macrophylla

被引：9

作者：

Do Tien Lam ^{[1
,2
]}

Vu Thi Thu Le ^{[1
,5
]}

Pham Minh Quan ^{[1
,2
]}

Pham Thi Hong Minh ^{[1
,2
]}

Ta Thi Thu Thuy ^{[3
]}

Nguyen Thi Ngoc Anh ^{[3
]}

Bui Huu Tai ^{[1
,4
]}

Phan Van Kiem ^{[1
,4
]}

机构：

[1] Vietnam Acad Sci & Technol, Grad Univ Sci & Technol, 18 Hoang Quoc Viet, Hanoi, Vietnam

[2] VAST, Inst Nat Prod Chem, 18 Hoang Quoc Viet, Hanoi, Vietnam

[3] Hanoi Open Univ, B101 Nguyen Hien, Hanoi, Vietnam

[4] VAST, Inst Marine Biochem, 18 Hoang Quoc Viet, Hanoi, Vietnam

[5] Thai Nguyen Univ Agr & Forestry, Thai Nguyen City, Vietnam

来源：

NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 07期

关键词：

Callicarpa macrophylla; Verbenaceae; callimacrophylla A; callimacrophylla B; DITERPENOIDS; GLYCOSIDES;

D O I：

10.1080/14786419.2019.1639180

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new terpenoids (1-2) and seven known compounds (3-9) were isolated from methanol extract of Callicarpa macrophylla leaves. Their structures were determined to be ent-7 alpha,16 beta,17,18-tetrahydroxykaur-15-one (1), 3 beta-acetoxy-urs-12-ene-11-one-12-ol (2), ent-1 beta-acetoxy-7 alpha,14 beta-dihydroxykaur-16-en-15-one (3), 3 beta-acetoxy-11 alpha,13 beta-dihydroxyolean-12-one (4), beta-amyrin (5), spinasterol (6), ursolic acid (7), beta-sitosterol (8), and daucosterol (9) by analyses of their MS, NMR spectroscopic data and by comparison with those reported in the literature. Compounds 1 - 4, and 7 displayed potential cytotoxic activity towards HepG-2, LU-1, and MCF-7 human cancer cell lines with IC50 values ranging from 0.46 +/- 0.21 to 18.14 +/- 0.33 mu M. Compound 6 showed IC50 values of 14.17 +/- 0.21 and 5.72 +/- 0.42 mu M against Hep-G2 and MCF-7 cell lines, respectively. [GRAPHICS] .

引用

页码：1107 / 1114

页数：8

共 27 条

[1]

Appalaraju G., 2014, Annals of Biological Research, V5, P39

[2]

BAN NT, 2003, CHECKLIST PLANT SPEC, V3

[3]

BARKATULLAH MI, 2015, AM J BIOMED LIFE SCI, V3, P1

[4] Structure of kaurane-type diterpenes from Parinari sprucei and their potential anticancer activity [J].

Braca, A ;

Armenise, A ;

Morelli, L ;

Mendez, J ;

Mi, QW ;

Chai, HB ;

Swanson, SM ;

Kinghorn, AD ;

De Tommasi, N .

PLANTA MEDICA, 2004, 70 (06) :540-550

[5]

Chi VV., 2012, Dictionary of Vietnamese Medicinal Plants

[6] Iridoid glycosides from Callicarpa nudiflora Hook [J].

Feng, Shi-Xiu ;

Yi, Bo ;

Zhang, Min ;

Xu, Jing ;

Lin, Hai ;

Xu, Wen-Tong .

NATURAL PRODUCT RESEARCH, 2017, 31 (02) :181-189

[7] ent-kaurane diterpenoids from Croton tonkinensis inhibit LPS-induced NF-κB activation and NO production [J].

Giang, PM ;

Jin, HZ ;

Son, PT ;

Lee, JH ;

Hong, YS ;

Lee, JJ .

JOURNAL OF NATURAL PRODUCTS, 2003, 66 (09) :1217-1220

[8]

GIANG PM, 2013, VIETNAM J CHEM, V51, P80

[9]

Goad L.J., 1997, Analysis of sterols

[10] Two New Oleanane-Type Triterpenes Isolated from Japanese Post-Fermented Tea Produced by Anaerobic Microbial Fermentation [J].

Huang, Yong-Lin ;

Nagai, Sachi ;

Tanaka, Takashi ;

Matsuo, Yosuke ;

Saito, Yoshinori ;

Kouno, Isao .

MOLECULES, 2013, 18 (05) :4868-4875

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