Two new terpenoids from the leaves of callicarpa macrophylla

Two new terpenoids (1-2) and seven known compounds (3-9) were isolated from methanol extract of Callicarpa macrophylla leaves. Their structures were determined to be ent-7 alpha,16 beta,17,18-tetrahydroxykaur-15-one (1), 3 beta-acetoxy-urs-12-ene-11-one-12-ol (2), ent-1 beta-acetoxy-7 alpha,14 beta-dihydroxykaur-16-en-15-one (3), 3 beta-acetoxy-11 alpha,13 beta-dihydroxyolean-12-one (4), beta-amyrin (5), spinasterol (6), ursolic acid (7), beta-sitosterol (8), and daucosterol (9) by analyses of their MS, NMR spectroscopic data and by comparison with those reported in the literature. Compounds 1 - 4, and 7 displayed potential cytotoxic activity towards HepG-2, LU-1, and MCF-7 human cancer cell lines with IC50 values ranging from 0.46 +/- 0.21 to 18.14 +/- 0.33 mu M. Compound 6 showed IC50 values of 14.17 +/- 0.21 and 5.72 +/- 0.42 mu M against Hep-G2 and MCF-7 cell lines, respectively. [GRAPHICS] .