Pathogenesis of juvenile idiopathic arthritis associated uveitis: the known and unknown

被引：48
作者：
Ayuso, Viera Kalinina [1 ]
Makhotkina, Nathalia [2 ]
van Tent-Hoeve, Maretta [1 ]
de Groot-Mijnes, Jolanda D. F. [1 ,3 ]
Wulffraat, Nico M. [4 ]
Rothova, Aniki [5 ]
de Boer, Joke H. [1 ]
机构：
[1] Univ Med Ctr Utrecht, Dept Ophthalmol, NL-3584 CX Utrecht, Netherlands
[2] Univ Med Ctr Maastricht, Dept Ophthalmol, Maastricht, Netherlands
[3] Univ Med Ctr Utrecht, Dept Virol, NL-3584 CX Utrecht, Netherlands
[4] Univ Med Ctr Utrecht, Dept Pediat, NL-3584 CX Utrecht, Netherlands
[5] Erasmus MC, Dept Ophthalmol, Rotterdam, Netherlands
来源：
SURVEY OF OPHTHALMOLOGY | 2014年 / 59卷 / 05期
关键词：
uveitis; juvenile idiopathic arthritis (JIA); pathogenesis; REGULATORY T-CELLS; EPSTEIN-BARR-VIRUS; EXPERIMENTAL AUTOIMMUNE UVEORETINITIS; FUCHS HETEROCHROMIC IRIDOCYCLITIS; MONOCLONAL-ANTIBODY RITUXIMAB; NECROSIS-FACTOR-ALPHA; RETINAL S-ANTIGEN; RHEUMATOID-ARTHRITIS; RUBELLA-VIRUS; ANTERIOR UVEITIS;
D O I：
10.1016/j.survophthal.2014.03.002
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease and the most prevalent systemic disorder in children with uveitis. The current prevailing opinion is that JIA is a multifactorial, genetically predisposed autoimmune disorder that can be influenced by environmental factors and infections; the specific pathogenesis of JIA-associated uveitis is not understood, however, nor has the relationship between the eye and joint inflammation been established. Nevertheless, subtypes of JIA that are associated with uveitis, oligoarthritis, polyarticular rheumatoid factor negative, and psoriatic arthritis appear to have common pathogenicity. We summarize our current knowledge regarding the pathogenesis of JIA-associated uveitis and discuss the possible role of immune responses and cytokine involvement, genetic associations, and the influence of external triggers in this disease-an association that is supported by data obtained from arthritis research and experimental uveitis models. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码：517 / 531
页数：15
相关论文
共 190 条
[1]   IL1 gene polymorphisms in enthesitis related arthritis category of juvenile idiopathic arthritis (ERA-JIA) [J].
Aggarwal, A. ;
Srivastava, R. ;
Singh, S. ;
Dubey, P. Kumar .
CLINICAL RHEUMATOLOGY, 2012, 31 (04) :607-611
[2]  
ALBANI S, 1994, CLIN EXP RHEUMATOL, V12, pS35
[3]   Efficacy and safety of repeat courses of rituximab treatment in patients with severe refractory juvenile idiopathic arthritis [J].
Alexeeva, Ekaterina I. ;
Valieva, Saniya I. ;
Bzarova, Tatyana M. ;
Semikina, Elena L. ;
Isaeva, Kseniya B. ;
Lisitsyn, Alexander O. ;
Denisova, Rina V. ;
Chistyakova, Evgeniya G. .
CLINICAL RHEUMATOLOGY, 2011, 30 (09) :1163-1172
[4]   The prevalence of human leukocyte antigen (HLA) DR/DQ/DP alleles in Kuwaiti children with oligoarticular juvenile idiopathic arthritis [J].
Alsaeid, K ;
Haider, MZ ;
Sharma, PN ;
Ayoub, EM .
RHEUMATOLOGY INTERNATIONAL, 2006, 26 (03) :224-228
[5]   TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1 [J].
Amadi-Obi, Ahjoku ;
Yu, Cheng-Rong ;
Liu, Xuebin ;
Mahdi, Rashid M. ;
Clarke, Grace Levy ;
Nussenblatt, Robert B. ;
Gery, Igal ;
Lee, Yun Sang ;
Egwuagu, Charles E. .
NATURE MEDICINE, 2007, 13 (06) :711-718
[6]   Vitamin D and autoimmunity: New aetiological and therapeutic considerations [J].
Arnson, Yoav ;
Amital, Howard ;
Shoenfeld, Yehuda .
ANNALS OF THE RHEUMATIC DISEASES, 2007, 66 (09) :1137-1142
[7]   Do infections trigger juvenile idiopathic arthritis? [J].
Aslan, Mustafa ;
Kasapcopur, Ozgur ;
Yasar, Hatice ;
Polat, Erdal ;
Saribas, Suat ;
Cakan, Huseyin ;
Dirican, Ahmet ;
Torun, Muzeyyen Mamal ;
Arisoy, Nil ;
Kocazeybek, Bekir .
RHEUMATOLOGY INTERNATIONAL, 2011, 31 (02) :215-220
[8]   Intraocular Biomarker Identification in Uveitis Associated With Juvenile Idiopathic Arthritis [J].
Ayuso, Viera Kalinina ;
de Boer, Joke H. ;
Byers, Helen L. ;
Coulton, Gary R. ;
Dekkers, Jojanneke ;
de Visser, Lenneke ;
van Loon, Anton M. ;
Schellekens, Peter A. W. J. F. ;
Rothova, Aniki ;
de Groot-Mijnes, Jolanda D. F. .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2013, 54 (05) :3709-3720
[9]   Male Gender as a Risk Factor for Complications in Uveitis Associated With Juvenile Idiopathic Arthritis [J].
Ayuso, Viera Kalinina ;
Ten Cate, Hermine Adriana Theodore ;
Van der Does, Patricia ;
Rothova, Aniki ;
De Boer, Joke Helena .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 2010, 149 (06) :994-999
[10]   Male Gender and Poor Visual Outcome in Uveitis Associated With Juvenile Idiopathic Arthritis [J].
Ayuso, Viera Kalinina ;
Ten Cate, Hermine Adriana Theodore ;
Van der Does, Patricia ;
Rothova, Aniki ;
De Boer, Joke Helena .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 2010, 149 (06) :987-993
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