Synthesis of 5-aryl-2-[spiro-(1,3-dithiolane)-2,4'-(3'-chloro-2'-azetidinon)-1'-yl]-1,3,4-oxa (thia)diazoles and 5-aryl-2-[spiro-(1,3-dithiolane)-2,2'-(4'-thiazolidinon)-3'-yl]-1,3,4-oxa(thia)diazoles as antimicrobial agents

被引：0
作者：
Khan, MH [1 ]
Nizamuddin [1 ]
机构：
[1] GORAKHPUR UNIV,DEPT CHEM,AGROCHEM RES LAB,GORAKHPUR 273009,UTTAR PRADESH,INDIA
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 1997年 / 36卷 / 07期
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D O I：
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
5-Aryl-2-[spiro-(1,3-dithiolane)-2,4'-(3'-chloro-2'-azetidinon)-1'-yl]-1,3,4-oxa(thia)diazoles 4 and 5- aryl-2-[spiro-(1,3-dithiolane)-2,2'-(4'-thiazolidinon)- 3'-yl]- 1,3,4-oxa (thia)-diazoles 5 have been synthesised from 5-aryl-2-(1,3-dithiolan-2-yl)imino-1,3,4-oxa(thia) diazoles 3 with chloro acetyl chloride and mercapto acetic acid, respectively. These compounds have been screened on Aspergillus niger, Pyricularia oryzae, Fusarium oxysporum and Cephalosporum sacchari; and Escherichia coli, Solmonella typhi and Bacillus aureus for their antifungal and antibacterial activities, respectively.
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页码：625 / 629
页数：5
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