Aphidicolin-sensitive specific common fragile sites: A biomarker of exposure to pesticides

被引：0

作者：

Musio, A ^{[1
]}

Sbrana, I ^{[1
]}

机构：

[1] UNIV PISA,DIPARTIMENTO SCI AMBIENTE & TERR,I-56100 PISA,ITALY

来源：

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS | 1997年 / 29卷 / 03期

关键词：

pesticide exposure; common fragile sites; cancer breakpoints; tumor development;

D O I：

10.1002/(SICI)1098-2280(1997)29:3<250::AID-EM4>3.0.CO;2-G

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

In this work, we analyzed the aphidicolin-sensitive common fragile sites in seven Females and four males occupationally exposed to pesticides and in ten controls. The same males had been monitored one year earlier in a previous study by the same authors. Results showed enhanced expression in exposed subjects at eight bands, namely, 6q25, 7p22, 7q22, 7q32, 13q14, 14q24, 16q22, and 16q23. Most of these bands were fragile sites and breakpoints involved in chromosome rearrangements found in hematopoietic tumors. Moreover, six of these bands were already detected, with enhanced expression, in the first monitoring carried out on male subjects. These results indicated that fragile sites analysis is a reproducible cell response to human exposure to pesticides. (C) 1997 Wiley-Liss, Inc.

引用

页码：250 / 255

页数：6