Imaging of drug and metabolite distribution by MS: case studies

被引：7

作者：

Takai, Nozomi ^{[1
]}

Tanaka, Yukari ^{[1
]}

机构：

[1] Shionogi & Co Ltd, Res Lab Dev, Toyonaka, Osaka 5610825, Japan

来源：

BIOANALYSIS | 2015年 / 7卷 / 20期

关键词：

IONIZATION MASS-SPECTROMETRY; EXTRACTION SURFACE-ANALYSIS; TISSUE; ABSORPTION;

D O I：

10.4155/bio.15.184

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Analysis of drug and metabolite distribution is essential for understanding of the mechanisms underlying the pharmacological or toxicological effects. MS imaging (MSI) can visualize the distribution of drugs or biological molecules in tissue sections without radiolabeling, and distinguish between the distribution of a drug and that of its metabolites in tissue sections. Therefore, it is expected to be a potent imaging technique for drug distribution studies. This article includes cases in which MSI was used to analyze drug and metabolite distribution, and discusses the impact of data obtained by MSI in drug discovery and development.

引用

页码：2639 / 2648

页数：10

共 15 条

[1] Matrix-assisted laser desorption mass spectrometry imaging for the examination of imipramine absorption by Straticell-RHE-EPI/001 an artificial model of the human epidermis
Avery, Jennie L.
McEwen, Andrew
Flinders, Bryn
Francese, Simona
Clench, Malcolm R.
[J]. XENOBIOTICA, 2011, 41 (08) : 735 - 742
[2] Central Nervous System Disposition and Metabolism of Fosdevirine (GSK2248761), a Non-Nucleoside Reverse Transcriptase Inhibitor: An LC-MS and Matrix-Assisted Laser Desorption/Ionization Imaging MS Investigation into Central Nervous System Toxicity
Castellino, Stephen
Groseclose, M. Reid
Sigafoos, James
Wagner, David
de Serres, Mark
Polli, Joseph W.
Romach, Elizabeth
Myer, James
Hamilton, Brad
[J]. CHEMICAL RESEARCH IN TOXICOLOGY, 2013, 26 (02) : 241 - 251
[3] Castellino S, 2011, BIOANALYSIS, V3, P2427, DOI [10.4155/BIO.11.232, 10.4155/bio.11.232]
[4] Chen Jiwen, 2008, Drug Metab Lett, V2, P1
[5] Utility of quantitative whole-body autoradiography (QWBA) and imaging mass spectrometry (IMS) by matrix-assisted laser desorption/ionization (MALDI) in the assessment of ocular distribution of drugs
Drexler, Dieter M.
Tannehill-Gregg, Sarah H.
Wang, Lifei
Brock, Barry J.
[J]. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2011, 63 (02) : 205 - 208
[6] Liquid extraction surface analysis mass spectrometry (LESA-MS) as a novel profiling tool for drug distribution and metabolism analysis: the terfenadine example
Eikel, Daniel
Vavrek, Marissa
Smith, Sheri
Bason, Carol
Yeh, Suzie
Korfmacher, Walter A.
Henion, Jack D.
[J]. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2011, 25 (23) : 3587 - 3596
[7] Direct Demonstration of Tissue Uptake of an Inhaled Drug: Proof-of-Principle Study Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging
Fehniger, Thomas E.
Vegvari, Akos
Rezeli, Melinda
Prikk, Kaiu
Ross, Peeter
Dahlback, Magnus
Edula, Goutham
Sepper, Ruth
Marko-Varga, Gyorgy
[J]. ANALYTICAL CHEMISTRY, 2011, 83 (21) : 8329 - 8336
[8] Evaluation of Therapeutics in Three-Dimensional Cell Culture Systems by MALDI Imaging Mass Spectrometry
Liu, Xin
Weaver, Eric M.
Hummon, Amanda B.
[J]. ANALYTICAL CHEMISTRY, 2013, 85 (13) : 6295 - 6302
[9] Correlation of Skin Blanching and Percutaneous Absorption for Glucocorticoid Receptor Agonists by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging and Liquid Extraction Surface Analysis with Nanoelectrospray Ionization Mass Spectrometry
Marshall, Peter
Toteu-Djomte, Valerie
Bareille, Philippe
Perry, Hayley
Brown, Gillian
Baumert, Mark
Biggadike, Keith
[J]. ANALYTICAL CHEMISTRY, 2010, 82 (18) : 7787 - 7794
[10] In Situ Mass Spectrometry Imaging and Ex Vivo Characterization of Renal Crystalline Deposits Induced in Multiple Preclinical Drug Toxicology Studies
Nilsson, Anna
Forngren, Benita
Bjurstrom, Sivert
Goodwin, Richard J. A.
Basmaci, Elisa
Gustafsson, Ingela
Annas, Anita
Hellgren, Dennis
Svanhagen, Alexander
Andren, Per E.
Lindberg, Johan
[J]. PLOS ONE, 2012, 7 (10):

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