Minimal residual disease in multiple myeloma: use of magnetic resonance imaging

被引:17
作者
Hillengass, Jens [1 ,2 ]
Merz, Maximilian [2 ]
Delorme, Stefan [3 ]
机构
[1] Roswell Pk Canc Inst, Dept Med, Buffalo, NY 14263 USA
[2] Heidelberg Univ, Dept Hematol Oncol & Rheumatol, Heidelberg, Germany
[3] German Canc Res Ctr, Dept Radiol, Heidelberg, Germany
关键词
Magnetic resonance imaging; Minimal Residual Disease; Multiple Myeloma; Treatment Monitoring; Prognosis; Response Assessment; WHOLE-BODY MRI; DIFFUSION-WEIGHTED MRI; PROGNOSTIC-SIGNIFICANCE; INFILTRATION; CHALLENGES; PATTERNS; SURVIVAL; LESIONS; BURDEN;
D O I
10.1053/j.seminhematol.2018.02.001
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The increasing percentage of patients achieving deep responses in multiple myeloma has led to the need for more sophisticated instruments to measure residual disease as a potential source of relapse. As minimal residual disease assessment is mostly performed on a bone marrow specimen from a certain area of the body, such samples have the limitation that they might not really represent the actual tumor burden, because focal accumulations of malignant cells might be either hit or missed. Magnetic resonance imaging is a highly sensitive technique for the assessment of tumor burden and can be performed as whole-body protocol, overcoming the problem of sampling error for minimal residual disease assessment. Despite its high sensitivity, however, magnetic resonance imaging cannot differentiate between vital and necrotic lesions after therapy. Therefore, new fusion and functional techniques are currently under investigation, and image-guided biopsies are performed to combine the strengths of all available methods. (C) 2018 Published by Elsevier Inc.
引用
收藏
页码:19 / 21
页数:3
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