Barriers to assessment and treatment of pain in laboratory animals

被引:11
作者
Karas, Alicia Z. [1 ]
机构
[1] Tufts Univ, Cummings Sch Vet Med, North Grafton, MA 01536 USA
关键词
D O I
10.1038/laban0706-38
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Pain is an undesirable potential consequence of many of the procedures conducted on animals in the course of scientific research, and in most cases it is unnecessary. The US Congress, the public, and laboratory animal medical professionals have indicated that pain should be prevented or minimized in Laboratory animals, yet there is ample evidence to suggest that unalleviated pain is still a problem for some Laboratory animals. This evidence is circumstantial to some extent but has its basis in problematic issues of pain control in both veterinary and human medicine. The author attempts to identify specific barriers to reduction of pain in Laboratory animals. She then seeks to determine the relative importance of each obstacle and to develop approaches to overcoming each obstacle.
引用
收藏
页码:38 / 45
页数:8
相关论文
共 16 条
[1]  
[Anonymous], 2000, American Heritage dictionary of the English language, V4th
[2]  
Balcombe JP, 2004, CONTEMP TOP LAB ANIM, V43, P42
[3]   Immune-derived opioids and peripheral antinociception [J].
Cabot, PJ .
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2001, 28 (03) :230-232
[4]  
ELLERY A W, 1985, Laboratory Animals (London), V19, P106
[5]   The effect of anaesthesia and surgery on plasma cytokine production [J].
Helmy, SAK ;
Wahby, MAM ;
El-Nawaway, M .
ANAESTHESIA, 1999, 54 (08) :733-738
[6]  
*INT VET AC PAIN M, MISS STAT
[7]   Plasma levels of interleukin-6 and interleukin-10 are affected by ketorolac as an adjunct to patient-controlled morphine after abdominal hysterectomy [J].
Kim, MH ;
Hahm, TS .
CLINICAL JOURNAL OF PAIN, 2001, 17 (01) :72-77
[8]  
MORTON D, 1992, NEW SCI, V134, P28
[9]   Decade of pain control and research gets into gear in USA [J].
Nelson, R .
LANCET, 2003, 362 (9390) :1129-1129
[10]  
*NIH CTR SCI REV, REV PROC INT REV G