Ligand-free Pd(II)-catalyzed cyclization of α-chloroimino-N-arylamides to synthesis of quinoxalin-2(1H)-ones

被引：1

作者：

Li, Dianjun ^{[1
,2
]}

Yang, Jinhui ^{[1
,2
]}

Fan, Xu ^{[2
]}

机构：

[1] Ningxia Univ, Sch Chem & Chem Engn, State Key Lab High Efficiency Utilizat Coal & Gre, Yinchuan 750021, Ningxia, Peoples R China

[2] Ningxia Univ, Sch Chem & Chem Engn, Yinchuan 750021, Ningxia, Peoples R China

来源：

TETRAHEDRON LETTERS | 2020年 / 61卷 / 48期

基金：

中国国家自然科学基金;

关键词：

Quinoxalin-2(1H)-ones; Pd(II)-catalyzed; 2-(N-arylcarbamoyl)-2-chloroiminoacetate; alpha-Aryl-alpha-chloroimino-N-arylamides; Cyclization; CRAFTS ALLYLIC ALKYLATION; RADICAL CYCLIZATION; DERIVATIVES; QUINOXALINONES; HETEROCYCLES; DESIGN; POTENT;

D O I：

10.1016/j.tetlet.2020.152556

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A ligand-free Pd(II)-catalyzed synthesis of quinoxalin-2(1H)-ones has been developed. Pd(TFA)(2) can induce ethyl 2-(N-arylcarbamoyl)-2-chloroiminoacetates to undergo cyclization to afford quinoxalin-2(1H)-one products in high yields in the presence of Na2CO3. This catalytic system is also effective to convert alpha-aryl-alpha-chloroimino-N-arylamides to the corresponding quinoxalin-2(1H)-one products via tandem N-Cl cleavage and N-arylation in moderate yields. The reaction described herein constitutes simple and effective approach towards quinoxalin-2(1H)-one derivatives. (C) 2020 Elsevier Ltd. All rights reserved.

引用

页数：5

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