First functionalization by metallation of the pyridine moiety of 4-methoxypyridopyrimidines.: Diazines:: Part 38

被引：15

作者：

Audoux, J ^{[1
]}

Plé, N ^{[1
]}

Turck, A ^{[1
]}

Quéguiner, G ^{[1
]}

机构：

[1] INSA, IRCOF, UMR 6014, Lab Chim Organ Fine & Heterocycl, F-76131 Mont St Aignan, France

来源：

TETRAHEDRON | 2004年 / 60卷 / 30期

关键词：

metallation; methoxypyridopyrimidines; functionalization;

D O I：

10.1016/j.tet.2004.05.061

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting from pyridopyrimidin-4(3H)-ones, a general synthetic route leading to 4-methoxypyridopyrimidines is described. The first lithiation and functionalization of the pyridine moiety has been studied. According to various structural parameters, the regioselectivity of the metallation is discussed. The functionalization of the 4-methoxypyridopyrimidines via the metallation reaction, provides an efficient process to access new substituted pyridopyrimidines. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：6353 / 6362

页数：10

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