A recessive X-linked mutation causes a threefold reduction of total body zinc accumulation in Drosophila melanogaster laboratory strains

被引：8

作者：

Afshar, Negar ^{[1
]}

Argunhan, Bilge ^{[1
]}

Bettedi, Lucia ^{[1
]}

Szular, Joanna ^{[1
]}

Missirlis, Fanis ^{[2
]}

机构：

[1] Queen Mary Univ London, Sch Biol & Chem Sci, London E1 4NS, England

[2] Ctr Invest & Estudios Avanzados, Dept Fisiol Biofis & Neurociencias, Mexico City 07360, DF, Mexico

来源：

FEBS OPEN BIO | 2013年 / 3卷

关键词：

Zinc deficiency; Genome wide association study; Sex-linked mutation; Vitamin B5; Pantothenate kinase; PKAN; PANTOTHENATE KINASE HOMOLOG; HEAVY-METAL HOMEOSTASIS; PANCREATIC ISLETS; REVEALS; BINDING; FAMILY; COPPER; MTF-1; METALLOTHIONEIN; DETOXIFICATION;

D O I：

10.1016/j.fob.2013.07.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A newly identified human locus on chromosome 15 was recently associated with zinc accumulation. Based on a prior report of a threefold difference in zinc accumulation between fumble(1) heterozygous mutants and control fly strains, it was suggested that phosphopantothenoylcysteine decarboxylase might affect zinc status through its effects on vitamin B5 (pantothenate) metabolism. We report here that outcrossed fumble(1) heterozygous mutant flies with low zinc content have been recovered, suggesting that pantothenate metabolism did not alter zinc homeostasis in fumble(1) heterozygous flies. We show instead that the Drosophila condition of low body zinc accumulation is an X-chromosome-linked recessive trait. (C) 2013 The Authors. Published by Elsevier B.V. on behalf of Federation of European Biochemical Societies. All rights reserved,

引用

页码：302 / 304

页数：3

共 17 条

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