The limits of reductionism in medicine: Could systems biology offer an alternative?

被引：295
作者：
Ahn, Andrew C. [1 ]
Tewari, Muneesh
Poon, Chi-Sang
Phillips, Russell S.
机构：
[1] Harvard Univ, Sch Med, Div Res & Educ Complemetary & Integrat Med Therap, Boston, MA 02115 USA
[2] Beth Israel Deaconess Med Ctr, Div Gen Med & Primary Care, Boston, MA 02215 USA
[3] MIT, Adv Study Program, Cambridge, MA 02139 USA
[4] Fred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98104 USA
[5] Harvard Univ, MIT, Div Hlth Sci & Technol, Cambridge, MA 02138 USA
[6] MIT, Computat & Syst Biol Initiat, Cambridge, MA 02139 USA
来源：
PLOS MEDICINE | 2006年 / 3卷 / 06期
关键词：
D O I：
10.1371/journal.pmed.0030208
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
[No abstract available]
引用
收藏
页码：709 / 713
页数：5
相关论文
共 42 条
  • [1] Robustness in bacterial chemotaxis
    Alon, U
    Surette, MG
    Barkai, N
    Leibler, S
    [J]. NATURE, 1999, 397 (6715) : 168 - 171
  • [2] [Anonymous], 1992, BEGINNINGS W SCI
  • [3] Development of genetic circuitry exhibiting toggle switch or oscillatory behavior in Escherichia coli
    Atkinson, MR
    Savageau, MA
    Myers, JT
    Ninfa, AJ
    [J]. CELL, 2003, 113 (05) : 597 - 607
  • [4] Robustness in simple biochemical networks
    Barkai, N
    Leibler, S
    [J]. NATURE, 1997, 387 (6636) : 913 - 917
  • [5] Biological rhythms - Circadian clocks limited by noise
    Barkai, N
    Leibler, S
    [J]. NATURE, 2000, 403 (6767) : 267 - 268
  • [6] Bertalanffy V.L., 1968, GEN SYSTEM THEORY
  • [7] The community of the self
    Buchman, TG
    [J]. NATURE, 2002, 420 (6912) : 246 - 251
  • [8] Burkitt-Gray A, 2003, GLOB TELECOMS BUS, P26
  • [9] Leroy Hood expounds the principles, practice and future of systems biology
    Carney, SL
    [J]. DRUG DISCOVERY TODAY, 2003, 8 (10) : 436 - 438
  • [10] Fulfilling the promise: drug discovery in the post-genomic era
    Chanda, SK
    Caldwell, JS
    [J]. DRUG DISCOVERY TODAY, 2003, 8 (04) : 168 - 174
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