ANIMAL MODELS OF DISEASE Classification and etiology of diabetes in dogs and cats

被引：121

作者：

Nelson, Richard W. ^{[1
]}

Reusch, Claudia E. ^{[2
]}

机构：

[1] Univ Calif Davis, Sch Vet Med, Dept Med & Epidemiol, Davis, CA 95616 USA

[2] Univ Zurich, Vetsuisse Fac, Clin Small Anim Internal Med, Zurich, Switzerland

来源：

JOURNAL OF ENDOCRINOLOGY | 2014年 / 222卷 / 03期

关键词：

diabetes; islet cells; autoimmune; obesity; insulin resistance; ISLET AMYLOID POLYPEPTIDE; BETA-CELL FAILURE; RISK-FACTORS; INSULIN CONCENTRATIONS; CHRONIC-PANCREATITIS; BODY CONDITION; TIME TRENDS; MELLITUS; GLUCOSE; SUSCEPTIBILITY;

D O I：

10.1530/JOE-14-0202

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetes mellitus is a common disease in dogs and cats. The most common form of diabetes in dogs resembles type 1 diabetes in humans. Studies suggest that genetics, an immune-mediated component, and environmental factors are involved in the development of diabetes in dogs. A variant of gestational diabetes also occurs in dogs. The most common form of diabetes in cats resembles type 2 diabetes in humans. A major risk factor in cats is obesity. Obese cats have altered expression of several insulin signaling genes and glucose transporters and are leptin resistant. Cats also form amyloid deposits within the islets of the pancreas and develop glucotoxicity when exposed to prolonged hyperglycemia. This review will briefly summarize our current knowledge about the etiology of diabetes in dogs and cats and illustrate the similarities among dogs, cats, and humans.

引用

页码：T1 / T9

页数：9

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