"The Race" to Clone BRCA1

被引：68

作者：

King, Mary-Claire ^{[1
,2
]}

机构：

[1] Univ Washington, Dept Med, Seattle, WA 98195 USA

[2] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA

来源：

SCIENCE | 2014年 / 343卷 / 6178期

关键词：

POLYMERASE CHAIN-REACTION; HUMAN-BREAST-CANCER; OVARIAN-CANCER; GENE BRCA1; INHERITED MUTATIONS; HUMAN DNA; CHROMOSOME-17Q21; FAMILIES; LINKAGE; POLYMORPHISMS;

D O I：

10.1126/science.1251900

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The existence of BRCA1 was proven in 1990 by mapping predisposition to young-onset breast cancer in families to chromosome 17q21. Knowing that such a gene existed and approximately where it lay triggered efforts by public and private groups to clone and sequence it. The press baptized the competition "the race" and reported on it in detail for the next 4 years. BRCA1 was positionally cloned in September 1994. Twenty years later, I reflect on "the race" and its consequences for breast cancer prevention and treatment.

引用

页码：1462 / 1465

页数：4

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