"The Race" to Clone BRCA1

被引：68
作者：
King, Mary-Claire [1 ,2 ]
机构：
[1] Univ Washington, Dept Med, Seattle, WA 98195 USA
[2] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA
来源：
SCIENCE | 2014年 / 343卷 / 6178期
关键词：
POLYMERASE CHAIN-REACTION; HUMAN-BREAST-CANCER; OVARIAN-CANCER; GENE BRCA1; INHERITED MUTATIONS; HUMAN DNA; CHROMOSOME-17Q21; FAMILIES; LINKAGE; POLYMORPHISMS;
D O I：
10.1126/science.1251900
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The existence of BRCA1 was proven in 1990 by mapping predisposition to young-onset breast cancer in families to chromosome 17q21. Knowing that such a gene existed and approximately where it lay triggered efforts by public and private groups to clone and sequence it. The press baptized the competition "the race" and reported on it in detail for the next 4 years. BRCA1 was positionally cloned in September 1994. Twenty years later, I reflect on "the race" and its consequences for breast cancer prevention and treatment.
引用
收藏
页码：1462 / 1465
页数：4
相关论文
共 36 条
  • [1] ANDERSON DE, 1972, J NATL CANCER I, V48, P1029
  • [2] Breast Cancer Screening and Diagnosis
    Bevers, Therese B.
    Anderson, Benjamin O.
    Bonaccio, Ermelinda
    Buys, Sandra
    Daly, Mary B.
    Dempsey, Peter J.
    Farrar, William B.
    Fleming, Irving
    Garber, Judy E.
    Harris, Randall E.
    Heerdt, Alexandra S.
    Helvie, Mark
    Huff, John G.
    Khakpour, Nazanin
    Khan, Seema A.
    Krontiras, Helen
    Lyman, Gary
    Rafferty, Elizabeth
    Shaw, Sara
    Smith, Mary Lou
    Tsangaris, Theodore N.
    Williams, Cheryl
    Yaneeklov, Thomas
    [J]. JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2009, 7 (10): : 1060 - 1096
  • [3] BOTSTEIN D, 1980, AM J HUM GENET, V32, P314
  • [4] BOWCOCK AM, 1993, AM J HUM GENET, V52, P718
  • [5] Broca P., 1866, TRAIT TUMEURS
  • [6] Two Decades After BRCA: Setting Paradigms in Personalized Cancer Care and Prevention
    Couch, Fergus J.
    Nathanson, Katherine L.
    Offit, Kenneth
    [J]. SCIENCE, 2014, 343 (6178) : 1466 - 1470
  • [7] A YAC-BASED, P1-BASED, AND COSMID-BASED PHYSICAL MAP OF THE BRCA1 REGION ON CHROMOSOME-17Q21
    COUCH, FJ
    CASTILLA, LH
    XU, JZ
    ABEL, KJ
    WELCSH, P
    KING, SE
    WONG, LH
    HO, PP
    MERAJVER, S
    BRODY, LC
    YIN, GY
    HAYES, ST
    GIESER, LM
    FLEJTER, WL
    GLOVER, TW
    FRIEDMAN, LS
    LYNCH, ED
    MEZA, JE
    KING, MC
    LAW, DJ
    DEAVEN, L
    BOWCOCK, AM
    COLLINS, FS
    WEBER, BL
    CHANDRASEKHARAPPA, SC
    [J]. GENOMICS, 1995, 25 (01) : 264 - 273
  • [8] PROGRAM DESCRIPTION - CENTER-DETUDE-DU-POLYMORPHISME-HUMAIN (CEPH) - COLLABORATIVE GENETIC-MAPPING OF THE HUMAN GENOME
    DAUSSET, J
    CANN, H
    COHEN, D
    LATHROP, M
    LALOUEL, JM
    WHITE, R
    [J]. GENOMICS, 1990, 6 (03) : 575 - 577
  • [9] Estrogen receptor α is a putative substrate for the BRCA1 ubiquitin ligase
    Eakin, Catherine M.
    MacCoss, Michael J.
    Finney, Gregory L.
    Klevit, Rachel E.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (14) : 5794 - 5799
  • [10] Finch AP, 2014, J CLIN ONCOL
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