Reactive radical scavenging and xanthine oxidase inhibition of proanthocyanidins from Carallia brachiata

被引：23
作者：
Phuwapraisirisan, Preecha
Sowanthip, Preecha
Miles, D. Howard
Tip-pyang, Santi [1 ]
机构：
[1] Chulalongkorn Univ, Fac Sci, Dept Chem, Nat Prod Res Unit, Bangkok 10330, Thailand
[2] Univ Cent Florida, Dept Chem, Orlando, FL 32816 USA
来源：
PHYTOTHERAPY RESEARCH | 2006年 / 20卷 / 06期
关键词：
Carallia brachiata; carallidin; antioxidant; proanthocyanidin; xanthine oxidase; radical scavenging;
D O I：
10.1002/ptr.1877
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Antioxidant-guided separation of Carallia brachiata bark led to a new A-type trimeric proanthocyanidin named carallidin (1), along with mahuarmin A (2) and p-hydroxy benzoic acid (3). The structure of 1 was fully characterized by interpretation of spectroscopic data and chemical means. Compounds 1 and 2 exhibited radical scavenging against DPPH (IC50 102 and 182 mu m) and superoxide radical (IC50 1.47 and 9.74 mu m). In addition, 1 and 2 also inhibited xanthine oxidase with IC, values of 12.9 and 16.0 mu m. Copyright (c) 2006 John Wiley & Sons, Ltd.
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页码：458 / 461
页数：4
相关论文
共 12 条
[1]  
[Anonymous], 1999, COMPREHENSIVE NATURA
[2]   PLANT PROANTHOCYANIDINS .6. CHIROPTICAL STUDIES .95. CIRCULAR-DICHROISM OF PROCYANIDINS [J].
BARRETT, MW ;
KLYNE, W ;
SCOPES, PM ;
FLETCHER, AC ;
PORTER, LJ ;
HASLAM, E .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1979, (10) :2375-2377
[3]   Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers [J].
Cos, P ;
Ying, L ;
Calomme, M ;
Hu, JP ;
Cimanga, K ;
Van Poel, B ;
Pieters, L ;
Vlietinck, AJ ;
Vanden Berghe, D .
JOURNAL OF NATURAL PRODUCTS, 1998, 61 (01) :71-76
[4]   (PLUS)-HYGROLINE MAJOR ALKALOID OF CARALLIA BRACHIATA (RHIZOPHORACEAE) [J].
FITZGERALD, JS .
AUSTRALIAN JOURNAL OF CHEMISTRY, 1965, 18 (04) :589-+
[5]   STUDIES ON THE CONSTITUENTS OF EPHEDRA .11. MAHUANNIN-B STRUCTURES OF MAHUANNIN-A AND MAHUANNIN-B HYPOTENSIVE PRINCIPLES OF EPHEDRA ROOTS [J].
HIKINO, H ;
SHIMOYAMA, N ;
KASAHARA, Y ;
TAKAHASHI, M ;
KONNO, C .
HETEROCYCLES, 1982, 19 (08) :1381-1384
[6]   Studies on the constituents of bark of Parameria laevigata Moldenke [J].
Kamiya, K ;
Watanabe, C ;
Endang, H ;
Umar, M ;
Satake, T .
CHEMICAL & PHARMACEUTICAL BULLETIN, 2001, 49 (05) :551-557
[7]   A new diglycosyl megastigmane from Carallia brachiata [J].
Ling, SK ;
Takashima, T ;
Tanaka, T ;
Fujioka, T ;
Mihashi, K ;
Kouno, I .
FITOTERAPIA, 2004, 75 (7-8) :785-788
[8]  
NORO T, 1983, CHEM PHARM BULL, V31, P3984
[9]   ANTIOXIDANT ACTIVITY OF TANNINS AND FLAVONOIDS IN EUCALYPTUS-ROSTRATA [J].
OKAMURA, H ;
MIMURA, A ;
YAKOU, Y ;
NIWANO, M ;
TAKAHARA, Y .
PHYTOCHEMISTRY, 1993, 33 (03) :557-561
[10]   PROCYANIDIN TRIMERS POSSESSING A DOUBLY LINKED STRUCTURE FROM AESCULUS-HIPPOCASTANUM [J].
SANTOSBUELGA, C ;
KOLODZIEIJ, H ;
TREUTTER, D .
PHYTOCHEMISTRY, 1995, 38 (02) :499-504
12