Ionically gelled alginate foams: Physical properties controlled by type, amount and source of gelling ions

被引：30

作者：

Andersen, Therese ^{[1
,2
]}

Melvik, Jan Egil ^{[1
]}

Gaserod, Olav ^{[1
]}

Alsberg, Eben ^{[3
,4
,5
]}

Christensen, Bjorn E. ^{[2
]}

机构：

[1] FMC BioPolymer AS NovaMatrix, N-1337 Sandvika, Norway

[2] Norwegian Univ Sci & Technol, NOBIPOL, Dept Biotechnol, N-7034 Trondheim, Norway

[3] Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106 USA

[4] Case Western Reserve Univ, Dept Orthopaed Surg, Cleveland, OH 44106 USA

[5] Case Western Reserve Univ, Natl Ctr Regenerat Med, Devis Gen Med Sci, Cleveland, OH 44106 USA

来源：

CARBOHYDRATE POLYMERS | 2014年 / 99卷

关键词：

Biomaterial; Polysaccharide; Porous; Hydrogel; Gelation; Gelation kinetics; DRUG-DELIVERY SYSTEMS; LOADED ALGINATE; SODIUM ALGINATE; BONE-FORMATION; IN-VITRO; HYDROGELS; TISSUE; SCAFFOLDS; DEGRADATION; CALCIUM;

D O I：

10.1016/j.carbpol.2013.08.036

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new and flexible method for preparation of dry macroporous alginate foams with the capability of absorbing physiological solutions has been developed, which may find use within areas such as wound healing, cell culture, drug delivery and tissue engineering. The present study demonstrates how the gelation rate of the alginate and degree of ionic crosslinking can be utilized to control the physical foam properties. The rate of released Ca2+/Sr2+ gelling ions available for interaction with the alginate was influenced by the concentration and physical characteristics of CaCO3/SrCO3 particles. The method of preparation of such foams allows, as described herein, tailoring of the pore structure, hydration properties and mechanical integrity in a manner not possible by other techniques. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：249 / 256

页数：8

共 54 条

[1] Regulating bone formation via controlled scaffold degradation [J].

Alsberg, E ;

Kong, HJ ;

Hirano, Y ;

Smith, MK ;

Albeiruti, A ;

Mooney, DJ .

JOURNAL OF DENTAL RESEARCH, 2003, 82 (11) :903-908

[2] RADIOIODINATION OF ALGINATE VIA COVALENTLY-BOUND TYROSINAMIDE ALLOWS MONITORING OF ITS FATE IN-VIVO [J].

ALSHAMKHANI, A ;

DUNCAN, R .

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, 1995, 10 (01) :4-13

[3]

Andersen T, 2011, SPR CARB CH, V37, P227, DOI 10.1039/9781849732765-00227

[4] Ionically Gelled Alginate Foams: Physical Properties Controlled by Operational and Macromolecular Parameters [J].

Andersen, Therese ;

Melvik, Jan Egil ;

Gasered, Olav ;

Alsberg, Eben ;

Christensen, Bjorn E. .

BIOMACROMOLECULES, 2012, 13 (11) :3703-3710

[5]

[Anonymous], TEST METHOD TENSILE, DOI [10.1520/D0638-14, DOI 10.1520/D0638-14]

[6] Alginate hydrogels as biomaterials [J].

Augst, Alexander D. ;

Kong, Hyun Joon ;

Mooney, David J. .

MACROMOLECULAR BIOSCIENCE, 2006, 6 (08) :623-633

[7] The influence of hydrogel modulus on the proliferation and differentiation of encapsulated neural stem cells [J].

Banerjee, Akhilesh ;

Arha, Manish ;

Choudhary, Soumitra ;

Ashton, Randolph S. ;

Bhatia, Surita R. ;

Schaffer, David V. ;

Kane, Ravi S. .

BIOMATERIALS, 2009, 30 (27) :4695-4699

[8] Porous Alginate Hydrogels: Synthetic Methods for Tailoring the Porous Texture [J].

Barbetta, Andrea ;

Barigelli, Elena ;

Dentini, Mariella .

BIOMACROMOLECULES, 2009, 10 (08) :2328-2337

[9] Injectable preformed scaffolds with shape-memory properties [J].

Bencherif, Sidi A. ;

Sands, R. Warren ;

Bhatta, Deen ;

Arany, Praveen ;

Verbeke, Catia S. ;

Edwards, David A. ;

Mooney, David J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (48) :19590-19595

[10] Wound healing dressings and drug delivery systems: A review [J].

Boateng, Joshua S. ;

Matthews, Kerr H. ;

Stevens, Howard N. E. ;

Eccleston, Gillian M. .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2008, 97 (08) :2892-2923

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