A case of lung adenocarcinoma with a concurrent EGFR mutation and ALK rearrangement: A case report and literature review

被引:17
作者
Xu, Chun-Wei [1 ]
Cai, Xue-Ying [2 ]
Shao, Yuan [3 ]
Li, Yang [4 ]
Shi, Ming-Wei [4 ]
Zhang, Li-Ying [1 ]
Wang, Lin [1 ]
Zhang, Yu-Ping [1 ]
Wang, Lu-Ping [1 ]
Tian, Yu-Wang [1 ]
机构
[1] Gen Mil Hosp Beijing PLA, Dept Pathol, Beijing 100700, Peoples R China
[2] Zhejiang Univ, Shaoxing Hosp, Shaoxing Peoples Hosp, Dept Internal Med, Shaoxing 312000, Zhejiang, Peoples R China
[3] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Surg Med, Xian 312000, Shaanxi, Peoples R China
[4] Gen Mil Hosp Beijing PLA, Dept Oncol, Beijing 100700, Peoples R China
关键词
non-small cell lung carcinoma; epidermal growth factor receptor gene mutation; echinoderm microtubule associated protein like 4-anaplastic lymphoma kinase fusion gene; adenocarcinoma; gefitinib; EML4-ALK FUSION GENE; FACTOR-RECEPTOR GENE; CANCER; GEFITINIB; FEATURES;
D O I
10.3892/mmr.2015.4001
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The echinoderm microtubule associated protein like 4-anaplastic lymphoma kinase (EML4-ALK) fusion is almost mutually exclusive to epidermal growth factor receptor (EGFR) or K-RAS mutation in non-small cell lung cancer (NSCLC), and it is extremely rare for patients to exhibit both mutations. The present study reported the case of a 71-year-old female diagnosed with adenocarcinoma, exhibiting mutations in EGFR and EML4-ALK. The present study treated this patient with EGFR-TK inhibitors, as the first line therapy, and gefitinib therapy revealed a good response until now. In addition, previously reported cases and associated literature were reviewed. The present study provided a greater understanding of the molecular biology and optimal treatment for patients with NSCLC with >1 driver mutation.
引用
收藏
页码:4370 / 4375
页数:6
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