Liposome-like fucopeptides as sialyl Lewis X mimetics

被引：26

作者：

Lin, CC ^{[1
]}

Kimura, T ^{[1
]}

Wu, SH ^{[1
]}

WeitzSchmidt, G ^{[1
]}

Wong, CH ^{[1
]}

机构：

[1] Scripps Res Inst, DEPT CHEM, LA JOLLA, CA 92037 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(96)00509-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several fucodipeptides and their liposome-like derivatives were prepared and tested as inhibitors of sialyl Lewis X binding to E-selectin. It has been found that trans-hydroxyproline (D or L) can be used to mimic the galactose residue of sialyl Lewis X, and the mimetic containing 3,4-dihydroxy-D-proline is the most active with IC50 value (50 mu M) 10-fold greater than sialyl Lewis X. Derivatization of a hydroxythreonine-containing fucodipeptides into a covalent liposome-like derivative, however, provides a mimetic with only IC50 similar to 30 mu M. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2755 / 2760

页数：6

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