Recently it has been shown that effects of aging and pathologically induced changes of basal ganglia structures may have quite similar effects on cognitive functions mediated by the medial prefrontal cortex. The question appears, if this pattern may be assignable to other cognitive functions that are mediated via the basal ganglia and medial prefrontal brain areas. Error processing is a component of executive functions that also depends on these areas and especially on the anterior cingulate cortex (ACC). Hence we ask, if error processing functions are differentially modulated by normal aging and basal ganglia diseases. Error processing mechanisms in these groups were investigated using a cognitive event-related potential (ERP), the error negativity. Enrolling an extended sample of young and elderly controls, as well as patients with Parkinson's and Huntington's disease, we show that modulations of error processing differ between aging, different basal ganglia diseases. Despite that the examined basal ganglia disorder groups (Parkinson's and Huntington's disease) differ in their age they show similar modulations in error processing, suggesting that aging effects are overridden by pathogenic effects. The study shows that it may be valuable to compare aging not only to different forms of basal ganglia disorders in order to gain knowledge about age- and disease-related mechanisms and the effects of these on cognitive functions. Diseases of the basal ganglia may impact error processing above and beyond the effects of normal aging. Although many aging, Parkinson's disease and Huntington's disease studies on error processing functions have already been published, this study ties together several related observations across all of these groups in one experiment. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.
机构:
WHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, Dortmund, Germany
Ruhr Univ Bochum, Dept Neurol, Huntington Ctr NRW, St Josef Hosp, Bochum, GermanyWHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, Dortmund, Germany
Beste, Christian
Saft, Carsten
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Ruhr Univ Bochum, Dept Neurol, Huntington Ctr NRW, St Josef Hosp, Bochum, GermanyWHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, Dortmund, Germany
Saft, Carsten
Andrich, Juergen
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h-index: 0
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Ruhr Univ Bochum, Dept Neurol, Huntington Ctr NRW, St Josef Hosp, Bochum, GermanyWHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, Dortmund, Germany
Andrich, Juergen
Gold, Ralf
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Ruhr Univ Bochum, Dept Neurol, Huntington Ctr NRW, St Josef Hosp, Bochum, GermanyWHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, Dortmund, Germany
Gold, Ralf
Falkenstein, Michael
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h-index: 0
机构:
WHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, Dortmund, GermanyWHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, Dortmund, Germany
机构:
WHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, D-44139 Dortmund, Germany
Ruhr Univ Bochum, St Josef Hosp, Huntingdon Ctr NRW, Dept Neurol, D-4630 Bochum, GermanyWHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, D-44139 Dortmund, Germany
Beste, Christian
Saft, Carsten
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机构:
Ruhr Univ Bochum, St Josef Hosp, Huntingdon Ctr NRW, Dept Neurol, D-4630 Bochum, GermanyWHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, D-44139 Dortmund, Germany
Saft, Carsten
Konrad, Carsten
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h-index: 0
机构:
Univ Munster, Dept Psychiat & Psychotherapy, Interdisciplinary Ctr Clin Res IZKF, Munster, GermanyWHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, D-44139 Dortmund, Germany
Konrad, Carsten
Andrich, Juergen
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h-index: 0
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Ruhr Univ Bochum, St Josef Hosp, Huntingdon Ctr NRW, Dept Neurol, D-4630 Bochum, GermanyWHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, D-44139 Dortmund, Germany
Andrich, Juergen
Habbel, Anne
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h-index: 0
机构:
Univ Munster, Dept Clin Radiol, Munster, GermanyWHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, D-44139 Dortmund, Germany
Habbel, Anne
Schepers, Inga
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h-index: 0
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Univ Munster, Dept Psychiat & Psychotherapy, Interdisciplinary Ctr Clin Res IZKF, Munster, GermanyWHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, D-44139 Dortmund, Germany
Schepers, Inga
Jansen, Andreas
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Univ Munster, Dept Neurol, Interdisciplinary Ctr Clin Res IZKF, D-4400 Munster, GermanyWHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, D-44139 Dortmund, Germany
Jansen, Andreas
Pfleiderer, Bettina
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h-index: 0
机构:
Univ Munster, Dept Clin Radiol, Munster, GermanyWHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, D-44139 Dortmund, Germany
Pfleiderer, Bettina
Falkenstein, Michael
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WHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, D-44139 Dortmund, GermanyWHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, D-44139 Dortmund, Germany
机构:
Royal S Hants Hosp, Med Res Council Hearing Res Southampton, Southampton SO 14OYG, Hants, EnglandRoyal S Hants Hosp, Med Res Council Hearing Res Southampton, Southampton SO 14OYG, Hants, England
Debener, S
Ullsperger, M
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h-index: 0
机构:Royal S Hants Hosp, Med Res Council Hearing Res Southampton, Southampton SO 14OYG, Hants, England
Ullsperger, M
Siegel, M
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h-index: 0
机构:Royal S Hants Hosp, Med Res Council Hearing Res Southampton, Southampton SO 14OYG, Hants, England
Siegel, M
Fiehler, K
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h-index: 0
机构:Royal S Hants Hosp, Med Res Council Hearing Res Southampton, Southampton SO 14OYG, Hants, England
Fiehler, K
von Cramon, DY
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h-index: 0
机构:Royal S Hants Hosp, Med Res Council Hearing Res Southampton, Southampton SO 14OYG, Hants, England
von Cramon, DY
Engel, AK
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h-index: 0
机构:Royal S Hants Hosp, Med Res Council Hearing Res Southampton, Southampton SO 14OYG, Hants, England
机构:
WHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, Dortmund, Germany
Ruhr Univ Bochum, Dept Neurol, Huntington Ctr NRW, St Josef Hosp, Bochum, GermanyWHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, Dortmund, Germany
Beste, Christian
Saft, Carsten
论文数: 0引用数: 0
h-index: 0
机构:
Ruhr Univ Bochum, Dept Neurol, Huntington Ctr NRW, St Josef Hosp, Bochum, GermanyWHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, Dortmund, Germany
Saft, Carsten
Andrich, Juergen
论文数: 0引用数: 0
h-index: 0
机构:
Ruhr Univ Bochum, Dept Neurol, Huntington Ctr NRW, St Josef Hosp, Bochum, GermanyWHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, Dortmund, Germany
Andrich, Juergen
Gold, Ralf
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h-index: 0
机构:
Ruhr Univ Bochum, Dept Neurol, Huntington Ctr NRW, St Josef Hosp, Bochum, GermanyWHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, Dortmund, Germany
Gold, Ralf
Falkenstein, Michael
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h-index: 0
机构:
WHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, Dortmund, GermanyWHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, Dortmund, Germany
机构:
WHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, D-44139 Dortmund, Germany
Ruhr Univ Bochum, St Josef Hosp, Huntingdon Ctr NRW, Dept Neurol, D-4630 Bochum, GermanyWHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, D-44139 Dortmund, Germany
Beste, Christian
Saft, Carsten
论文数: 0引用数: 0
h-index: 0
机构:
Ruhr Univ Bochum, St Josef Hosp, Huntingdon Ctr NRW, Dept Neurol, D-4630 Bochum, GermanyWHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, D-44139 Dortmund, Germany
Saft, Carsten
Konrad, Carsten
论文数: 0引用数: 0
h-index: 0
机构:
Univ Munster, Dept Psychiat & Psychotherapy, Interdisciplinary Ctr Clin Res IZKF, Munster, GermanyWHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, D-44139 Dortmund, Germany
Konrad, Carsten
Andrich, Juergen
论文数: 0引用数: 0
h-index: 0
机构:
Ruhr Univ Bochum, St Josef Hosp, Huntingdon Ctr NRW, Dept Neurol, D-4630 Bochum, GermanyWHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, D-44139 Dortmund, Germany
Andrich, Juergen
Habbel, Anne
论文数: 0引用数: 0
h-index: 0
机构:
Univ Munster, Dept Clin Radiol, Munster, GermanyWHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, D-44139 Dortmund, Germany
Habbel, Anne
Schepers, Inga
论文数: 0引用数: 0
h-index: 0
机构:
Univ Munster, Dept Psychiat & Psychotherapy, Interdisciplinary Ctr Clin Res IZKF, Munster, GermanyWHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, D-44139 Dortmund, Germany
Schepers, Inga
Jansen, Andreas
论文数: 0引用数: 0
h-index: 0
机构:
Univ Munster, Dept Neurol, Interdisciplinary Ctr Clin Res IZKF, D-4400 Munster, GermanyWHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, D-44139 Dortmund, Germany
Jansen, Andreas
Pfleiderer, Bettina
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h-index: 0
机构:
Univ Munster, Dept Clin Radiol, Munster, GermanyWHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, D-44139 Dortmund, Germany
Pfleiderer, Bettina
Falkenstein, Michael
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h-index: 0
机构:
WHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, D-44139 Dortmund, GermanyWHO Collaborating Ctr Occupat Hlth & Human Factor, Leibniz Res Ctr Working Environm & Human Factors, D-44139 Dortmund, Germany
机构:
Royal S Hants Hosp, Med Res Council Hearing Res Southampton, Southampton SO 14OYG, Hants, EnglandRoyal S Hants Hosp, Med Res Council Hearing Res Southampton, Southampton SO 14OYG, Hants, England
Debener, S
Ullsperger, M
论文数: 0引用数: 0
h-index: 0
机构:Royal S Hants Hosp, Med Res Council Hearing Res Southampton, Southampton SO 14OYG, Hants, England
Ullsperger, M
Siegel, M
论文数: 0引用数: 0
h-index: 0
机构:Royal S Hants Hosp, Med Res Council Hearing Res Southampton, Southampton SO 14OYG, Hants, England
Siegel, M
Fiehler, K
论文数: 0引用数: 0
h-index: 0
机构:Royal S Hants Hosp, Med Res Council Hearing Res Southampton, Southampton SO 14OYG, Hants, England
Fiehler, K
von Cramon, DY
论文数: 0引用数: 0
h-index: 0
机构:Royal S Hants Hosp, Med Res Council Hearing Res Southampton, Southampton SO 14OYG, Hants, England
von Cramon, DY
Engel, AK
论文数: 0引用数: 0
h-index: 0
机构:Royal S Hants Hosp, Med Res Council Hearing Res Southampton, Southampton SO 14OYG, Hants, England