A stochastic model for kinesin bidirectional stepping

被引：2
|
作者：
Yao, Xiaojun [1 ,2 ]
Zheng, Yujun [1 ]
机构：
[1] Shandong Univ, Sch Phys, Jinan 250100, Peoples R China
[2] Shandong Univ, Taishan Coll, Jinan 250100, Peoples R China
来源：
JOURNAL OF CHEMICAL PHYSICS | 2014年 / 140卷 / 08期
基金：
美国国家科学基金会;
关键词：
HAND-OVER-HAND; DOUBLE-HEADED BINDING; KINETIC MECHANISM; LOADING DIRECTION; MOLECULAR MOTORS; 8-NM STEP; MICROTUBULE; HYDROLYZES; MOTILITY; RATCHETS;
D O I：
10.1063/1.4865934
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
In this paper, a hand-over-hand stochastic model for the dynamics of the conventional kinesin is constructed. In the model, both forward and backward motions are taken into consideration. First passage time distributions, average velocities, dwell times, and forward/backward step ratios are investigated based on the model. A good agreement between the results of the model and experimental data is achieved under a variety of external loads. (C) 2014 AIP Publishing LLC.
引用
收藏
页数：8
相关论文
共 50 条
  • [41] Kinesin motor mechanics: Binding, stepping, tracking, gating, and limping
    Block, Steven M.
    BIOPHYSICAL JOURNAL, 2007, 92 (09) : 2986 - 2995
  • [42] Stochastic bidirectional training
    Gedeon, TD
    1998 IEEE INTERNATIONAL CONFERENCE ON SYSTEMS, MAN, AND CYBERNETICS, VOLS 1-5, 1998, : 1968 - 1971
  • [43] Reconstitution of DDB-kinesin bidirectional transport in vitro
    Gicking, Allison M.
    Hancock, William O.
    BIOPHYSICAL JOURNAL, 2022, 121 (03) : 400A - 400A
  • [44] Regulation of Bidirectional Motility of Kinesin-5 Motors
    Gheber, Leah
    BIOPHYSICAL JOURNAL, 2019, 116 (03) : 35A - 35A
  • [45] Reconstitution of DDB-Kinesin Bidirectional Transport In Vitro
    Gicking, Allison
    Hancock, William O.
    BIOPHYSICAL JOURNAL, 2021, 120 (03) : 167A - 167A
  • [46] Fast and accurate long-stepping simulation of the Heston stochastic volatility model
    Chan, Jiun Hong
    Joshi, Mark
    JOURNAL OF COMPUTATIONAL FINANCE, 2013, 16 (03) : 47 - 97
  • [47] Stepping and stretching - How kinesin uses internal strain to walk processively
    Rosenfeld, SS
    Fordyce, PM
    Jefferson, GM
    King, PH
    Block, SM
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (20) : 18550 - 18556
  • [48] Kinesin's biased stepping mechanism: Amplification of neck linker zippering
    Mather, William H.
    Fox, Ronald F.
    BIOPHYSICAL JOURNAL, 2006, 91 (07) : 2416 - 2426
  • [49] Force-induced bidirectional stepping of cytoplasmic dynein
    Gennerich, Arne
    Carter, Andrew P.
    Reck-Peterson, Samara L.
    Vale, Ronald D.
    CELL, 2007, 131 (05) : 952 - 965
  • [50] A STEPPING STONE TO STOCHASTIC-ANALYSIS
    DEWITTMORETTE, C
    ELWORTHY, KD
    PHYSICS REPORTS-REVIEW SECTION OF PHYSICS LETTERS, 1981, 77 (03): : 125 - 167
12345