A stochastic model for kinesin bidirectional stepping

被引：2
|
作者：
Yao, Xiaojun [1 ,2 ]
Zheng, Yujun [1 ]
机构：
[1] Shandong Univ, Sch Phys, Jinan 250100, Peoples R China
[2] Shandong Univ, Taishan Coll, Jinan 250100, Peoples R China
来源：
JOURNAL OF CHEMICAL PHYSICS | 2014年 / 140卷 / 08期
基金：
美国国家科学基金会;
关键词：
HAND-OVER-HAND; DOUBLE-HEADED BINDING; KINETIC MECHANISM; LOADING DIRECTION; MOLECULAR MOTORS; 8-NM STEP; MICROTUBULE; HYDROLYZES; MOTILITY; RATCHETS;
D O I：
10.1063/1.4865934
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
In this paper, a hand-over-hand stochastic model for the dynamics of the conventional kinesin is constructed. In the model, both forward and backward motions are taken into consideration. First passage time distributions, average velocities, dwell times, and forward/backward step ratios are investigated based on the model. A good agreement between the results of the model and experimental data is achieved under a variety of external loads. (C) 2014 AIP Publishing LLC.
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页数：8
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