Synthesis, dimerization, and biological activity of hexaoxygenated chalcones related to calythropsin and combretastatins

被引：6
作者：
Seguin, E
Elomri, A
Magiatis, P
Skaltsounis, AL
Chao, LR
Tillequin, F
机构：
[1] Univ Rouen, UFR Med Pharm, Lab Pharmacognosie, F-76183 Rouen, France
[2] Univ Athens, Dept Pharm, Lab Pharmacognosy, GR-15771 Athens, Greece
[3] Univ Paris 05, Fac Pharm, CNRS, UMR 8638,Lab Pharmacognosie, F-75006 Paris, France
来源：
NATURAL PRODUCT LETTERS | 2002年 / 16卷 / 03期
关键词：
chalcone; cytotoxicity; tubuline assembly; aldol condensation; photochemical dimerization; cyclobutane;
D O I：
10.1080/10575630290010993
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Five new hexaoxygenated chalcones and one new chalcone photodimer were synthesized and their cytotoxicity against leukemia cell line L-1210 was studied. The three more active compounds were tested for their activity on the inhibition and promotion of tubulin assembly and it was found that these chalcones do not interfere with the tubulin-microtubule system at cytotoxic concentrations, and therefore operate by some different mechanism of action.
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页码：187 / 193
页数：7
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