Mirror Image of the Amyloid-β Species in Cerebrospinal Fluid and Cerebral Amyloid in Alzheimer's Disease

被引：10

作者：

Catania, Marcella ^{[1
]}

Di Fede, Giuseppe ^{[1
]}

Tonoli, Elisa ^{[2
]}

Benussi, Luisa ^{[2
]}

Pasquali, Claudio ^{[1
]}

Giaccone, Giorgio ^{[1
]}

Maderna, Emanuela ^{[1
]}

Ghidoni, Roberta ^{[2
]}

Tagliavini, Fabrizio ^{[1
]}

机构：

[1] IRCCS Fdn, Carlo Besta Neurol Inst, Div Neurol & Neuropathol 5, I-20133 Milan, Italy

[2] IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell, Mol Markers Lab, Brescia, Italy

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2015年 / 47卷 / 04期

关键词：

Alzheimer's disease; amyloid-beta; biomarker; cerebrospinal fluid; SELDI-TOF MS; PEPTIDE; MUTATION; PROTEIN; WATER; GENE;

D O I：

10.3233/JAD-150179

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer's disease (AD) is characterized by amyloid-beta (A beta) accumulation in brain that is paralleled by A beta(1-42) reduction in cerebrospinal fluid (CSF). We analyzed the pattern of A beta peptides, including the N- and C-terminal truncated fragments, in brain and CSF from two familial and one sporadic AD cases. We found that (i) each patient is characterized by a distinct A beta profile in CSF and brain deposits and (ii) the CSF A beta pattern mirrors the A beta profile of cerebral amyloid. These results suggest the existence of different molecular AD subtypes which can be recognized by CSF analysis, enabling patient stratification.

引用

页码：877 / 881

页数：5

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