Mirror Image of the Amyloid-β Species in Cerebrospinal Fluid and Cerebral Amyloid in Alzheimer's Disease

被引：10
|
作者：
Catania, Marcella [1 ]
Di Fede, Giuseppe [1 ]
Tonoli, Elisa [2 ]
Benussi, Luisa [2 ]
Pasquali, Claudio [1 ]
Giaccone, Giorgio [1 ]
Maderna, Emanuela [1 ]
Ghidoni, Roberta [2 ]
Tagliavini, Fabrizio [1 ]
机构：
[1] IRCCS Fdn, Carlo Besta Neurol Inst, Div Neurol & Neuropathol 5, I-20133 Milan, Italy
[2] IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell, Mol Markers Lab, Brescia, Italy
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2015年 / 47卷 / 04期
关键词：
Alzheimer's disease; amyloid-beta; biomarker; cerebrospinal fluid; SELDI-TOF MS; PEPTIDE; MUTATION; PROTEIN; WATER; GENE;
D O I：
10.3233/JAD-150179
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Alzheimer's disease (AD) is characterized by amyloid-beta (A beta) accumulation in brain that is paralleled by A beta(1-42) reduction in cerebrospinal fluid (CSF). We analyzed the pattern of A beta peptides, including the N- and C-terminal truncated fragments, in brain and CSF from two familial and one sporadic AD cases. We found that (i) each patient is characterized by a distinct A beta profile in CSF and brain deposits and (ii) the CSF A beta pattern mirrors the A beta profile of cerebral amyloid. These results suggest the existence of different molecular AD subtypes which can be recognized by CSF analysis, enabling patient stratification.
引用
收藏
页码：877 / 881
页数：5
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