Localization of α1-2 Fucose Glycan in the Mouse Olfactory Pathway

被引:17
|
作者
Kondoh, Daisuke [1 ]
Kamikawa, Akihiro [2 ]
Sasaki, Motoki [1 ]
Kitamura, Nobuo [1 ]
机构
[1] Obihiro Univ Agr & Vet Med, Lab Vet Anat, Dept Basic Vet Med, Inada Cho, Obihiro, Hokkaido 0808555, Japan
[2] Obihiro Univ Agr & Vet Med, Labs Vet Physiol, Dept Basic Vet Med, Obihiro, Hokkaido 0808555, Japan
关键词
alpha; 1-2; Fucose; Anterior olfactory nucleus; Glycosylation; Lateral olfactory tract; Olfactory bulb; Olfactory epithelium; Olfactory tubercle; Piriform cortex; Ulex europaeus agglutinin-I; Vomeronasal epithelium; CELL-ADHESION MOLECULE; LONG-TERM POTENTIATION; VOMERONASAL SYSTEM; N-GLYCANS; NEURONS; AXONS; RAT; MICE; IDENTIFICATION; EXPRESSION;
D O I
10.1159/000447009
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
Glycoconjugates in the olfactory system play critical roles in neuronal formation, and alpha 1-2 fucose (alpha 1-2Fuc) glycan mediates neurite outgrowth and synaptic plasticity. Histochemical findings of a1-2Fuc glycan in the mouse olfactory system detected using Ulex europaeus agglutinin-I (UEA-I) vary. This study histochemically assessed the main olfactory and vomeronasal pathways in male and female ICR and C57BL/6J mice aged 3-4 months using UEA-I. Ulex europaeus agglutinin-I reacted with most receptor cells arranged mainly at the basal region of the olfactory epithelium. The olfactory nerve layer and glomerular layer of the main olfactory bulb were speckled with positive UEA-I staining, and positive fibers were scattered from the glomerular to the internal plexiform layer. The lateral olfactory tract and rostral migratory stream were also positive for UEA-I. We identified superficial shortaxon cells, interneurons of the external plexiform layer, external, middle and internal tufted cells, mitral cells and granule cells as the origins of the UEA-I-positive fibers in the main olfactory bulb. The anterior olfactory nucleus, anterior piriform cortex and olfactory tubercle were negative for UEA-I. Most receptor cells in the vomeronasal epithelium and most glomeruli of the accessory olfactory bulb were positive for UEA-I. Our findings indicated that alpha 1-2Fuc glycan is located within the primary and secondary, but not the ternary, pathways of the main olfactory system, in local circuits of the main olfactory bulb and within the primary, but not secondary, pathway of the vomeronasal system. (C) 2016 S. Karger AG, Basel
引用
收藏
页码:20 / 28
页数:9
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