Progressive Age-Related Cognitive Decline in Tau Mice

被引：36

作者：

Van der Jeugd, Ann ^{[1
]}

Vermaercke, Ben ^{[1
]}

Derisbourg, Maxime ^{[2
,3
]}

Lo, Adrian C. ^{[1
]}

Hamdane, Malika ^{[2
,3
]}

Blum, David ^{[2
,3
,4
]}

Buee, Luc ^{[2
,3
,4
]}

D'Hooge, Rudi ^{[1
]}

机构：

[1] Univ Leuven, Fac Psychol & Educ Sci, Lab Biol Psychol, Louvain, Belgium

[2] Univ Lille Nord France, UDSL, Lille, France

[3] INSERM, Jean Pierre Aubert Res Ctr, IMPRT, U837, F-59045 Lille, France

[4] CHRU Lille, CMRR, F-59037 Lille, France

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2013年 / 37卷 / 04期

关键词：

aging; learning; memory; tauopathy; transgenic model; AMYLOID PRECURSOR PROTEIN; TRANSGENIC MOUSE MODEL; LONG-TERM POTENTIATION; MORRIS WATER MAZE; ALZHEIMERS-DISEASE; SYNAPTIC-TRANSMISSION; MEMORY DEFICITS; DEPENDENT IMPAIRMENT; ODOR DISCRIMINATION; HIPPOCAMPAL-NEURONS;

D O I：

10.3233/JAD-130110

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Age-related cognitive decline and neurodegenerative diseases are a growing challenge for society. Accumulation of tau pathology has been proposed to partially contribute to these impairments. This study provides a behavioral characterization during aging of transgenic mice bearing tau mutations. THY-Tau22 mice were evaluated at ages wherein tau neuropathology in this transgenic mouse model is low (3-4 months), moderate (6-7 months), or extensive (>9 months). Spatial memory was found to be impaired only after 9 months of age in THY-Tau22 mice, whereas non-spatial memory was affected as early as 6 months, appearing to offer an opportunity for assessing potential therapeutic agents in attenuating or preventing tauopathies through modulation of tau kinetics.

引用

页码：777 / 788

页数：12

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