Progressive Age-Related Cognitive Decline in Tau Mice

被引：37

作者：

Van der Jeugd, Ann ^{[1
]}

Vermaercke, Ben ^{[1
]}

Derisbourg, Maxime ^{[2
,3
]}

Lo, Adrian C. ^{[1
]}

Hamdane, Malika ^{[2
,3
]}

Blum, David ^{[2
,3
,4
]}

Buee, Luc ^{[2
,3
,4
]}

D'Hooge, Rudi ^{[1
]}

机构：

[1] Univ Leuven, Fac Psychol & Educ Sci, Lab Biol Psychol, Louvain, Belgium

[2] Univ Lille Nord France, UDSL, Lille, France

[3] INSERM, Jean Pierre Aubert Res Ctr, IMPRT, U837, F-59045 Lille, France

[4] CHRU Lille, CMRR, F-59037 Lille, France

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2013年 / 37卷 / 04期

关键词：

aging; learning; memory; tauopathy; transgenic model; AMYLOID PRECURSOR PROTEIN; TRANSGENIC MOUSE MODEL; LONG-TERM POTENTIATION; MORRIS WATER MAZE; ALZHEIMERS-DISEASE; SYNAPTIC-TRANSMISSION; MEMORY DEFICITS; DEPENDENT IMPAIRMENT; ODOR DISCRIMINATION; HIPPOCAMPAL-NEURONS;

D O I：

10.3233/JAD-130110

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Age-related cognitive decline and neurodegenerative diseases are a growing challenge for society. Accumulation of tau pathology has been proposed to partially contribute to these impairments. This study provides a behavioral characterization during aging of transgenic mice bearing tau mutations. THY-Tau22 mice were evaluated at ages wherein tau neuropathology in this transgenic mouse model is low (3-4 months), moderate (6-7 months), or extensive (>9 months). Spatial memory was found to be impaired only after 9 months of age in THY-Tau22 mice, whereas non-spatial memory was affected as early as 6 months, appearing to offer an opportunity for assessing potential therapeutic agents in attenuating or preventing tauopathies through modulation of tau kinetics.

引用

页码：777 / 788

页数：12

共 77 条

[1]

ALVAREZ P, 1995, J NEUROSCI, V15, P3796

[2] Accelerated Human Mutant Tau Aggregation by Knocking Out Murine Tau in a Transgenic Mouse Model [J].

Ando, Kunie ;

Leroy, Karelle ;

Heraud, Celine ;

Yilmaz, Zehra ;

Authelet, Michele ;

Suain, Valerie ;

De Decker, Robert ;

Brion, Jean-Pierre .

AMERICAN JOURNAL OF PATHOLOGY, 2011, 178 (02) :803-816

[3] Multi-metric behavioral comparison of APPsw and P30IL models for Alzheimer's Disease: linkage of poorer cognitive performance to tau pathology in forebrain [J].

Arendash, GW ;

Lewis, J ;

Leighty, RE ;

McGowan, E ;

Cracchiolo, JR ;

Hutton, M ;

Garcia, MF .

BRAIN RESEARCH, 2004, 1012 (1-2) :29-41

[4] Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes [J].

Arendash, GW ;

King, DL ;

Gordon, MN ;

Morgan, D ;

Hatcher, JM ;

Hope, CE ;

Diamond, DM .

BRAIN RESEARCH, 2001, 891 (1-2) :42-53

[5]

Auer S, 1997, Int Psychogeriatr, V9 Suppl 1, P167, DOI 10.1017/S1041610297004869

[6] Age-Dependent Impairment of Spine Morphology and Synaptic Plasticity in Hippocampal CA1 Neurons of a Presenilin 1 Transgenic Mouse Model of Alzheimer's Disease [J].

Auffret, Alexandra ;

Gautheron, Vanessa ;

Repici, Mariaelena ;

Kraftsik, Rudolf ;

Mount, Howard T. J. ;

Mariani, Jean ;

Rovira, Catherine .

JOURNAL OF NEUROSCIENCE, 2009, 29 (32) :10144-10152

[7] Olfactory Memory Impairment in Neurodegenerative Diseases [J].

Bahuleyan, Biju ;

Singh, Satendra .

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2012, 6 (08) :1437-1441

[8]

Balschun D, 2003, J NEUROSCI, V23, P6304

[9] MEMORY DEFICITS ASSOCIATED WITH SENESCENCE - NEUROPHYSIOLOGICAL AND BEHAVIORAL-STUDY IN THE RAT [J].

BARNES, CA .

JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1979, 93 (01) :74-104

[10] Early Tau Pathology Involving the Septo-Hippocampal Pathway in a Tau Transgenic Model: Relevance to Alzheimer's Disease [J].

Belarbi, Karim ;

Schindowski, Katharina ;

Burnouf, Sylvie ;

Caillierez, Raphaelle ;

Grosjean, Marie-Eve ;

Demeyer, Dominique ;

Hamdane, Malika ;

Sergeant, Nicolas ;

Blum, David ;

Buee, Luc .

CURRENT ALZHEIMER RESEARCH, 2009, 6 (02) :152-157

← 1 2 3 4 5 6 7 8 →