The antivascular actions of mild intensity ultrasound on a murine neoplasm

被引：0

作者：

Wood, Andrew K. W. ^{[1
]}

Bunte, Ralph M. ^{[2
]}

Ansaloni, Sara ^{[3
]}

Lee, William M. -F. ^{[4
]}

Sehgal, Chandra M. ^{[3
]}

机构：

[1] Univ Penn, Sch Vet Med, Dept Clin Studies, 3900 Delancey St, Philadelphia, PA 19104 USA

[2] Univ Penn, Univ Lab Anim Resources, Philadelphia, PA 19104 USA

[3] Univ Penn Med Ctr, Dept Radiol, Philadelphia, PA 19104 USA

[4] Univ Penn Med Ctr, Dept Med, Philadelphia, PA 19104 USA

来源：

THERAPEUTIC ULTRASOUND | 2006年 / 829卷

关键词：

cancer therapy; physiotherapy; vascular disrupting agent; tumor angiogenesis; power Doppler; vascular targeting agent; ultrasound bioeffects; ultrasound contrast agent;

D O I：

暂无

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

This study was aimed at determining whether mild intensity ultrasound affected the fragile and leaky angiogenic blood vessels in a tumor. In 27 mice (C3HV/HeN strain) a subcutaneous melanoma (K1735(22)) was insonated with continuous physiotherapy ultrasound (I MHz; spatial-average-temporal-average = 2.3 W cm(-2)). Analyses of contrast enhanced power Doppler observations showed that insonation significantly increased the avascular area in the neoplasm. A linear regression analysis demonstrated that each min of insonation lead to a 25% reduction in tumor vascularity. The predominant acute effect of insonation was an apparently irreparable dilation of the tumor capillaries; liquefactive necrosis of neoplastic cells, related to a secondary ischemia, was a delayed effect.

引用

页码：467 / +

页数：2

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