The Role of inhibitory Receptors in Monosodium Urate Crystal-induced Inflammation

被引：15

作者：

Fernandes, Maria J. ^{[1
]}

Naccache, Paul H. ^{[1
]}

机构：

[1] Laval Univ, Fac Med, CHU Quebec Res Ctr, Dept Microbiol Infect Dis & Immunol, Quebec City, PQ, Canada

来源：

FRONTIERS IN IMMUNOLOGY | 2018年 / 9卷

基金：

加拿大健康研究院;

关键词：

monosodium urate crystals; inflammation; gout; inhibitory receptors; neutrophils; NEUTROPHIL EXTRACELLULAR TRAPS; URIC-ACID CRYSTALS; C-TYPE LECTINS; RHEUMATOID-ARTHRITIS; HUMAN PHAGOCYTES; DENDRITIC CELLS; IMMUNE-SYSTEM; MICL CLEC12A; GOUT; ACTIVATION;

D O I：

10.3389/fimmu.2018.01883

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Inhibitory receptors are key regulators of immune responses. Aberrant inhibitory receptor function can either lead to an exacerbated or defective immune response. Several regulatory mechanisms involved in the inflammatory reaction induced by monosodium urate crystals (MSU) during acute gout have been identified. One of these mechanisms involves inhibitory receptors. The engagement of the inhibitory receptors Clec12A and SIRL-1 has opposing effects on the responses of neutrophils to MSU. We review the general concepts of inhibitory receptor biology and apply them to understand and compare the modulation of MSU-induced inflammation by Clec12A and SIRL-1. We also discuss gaps in our knowledge of the contribution of inhibitory receptors to the pathogenesis of gout and propose future avenues of research.

引用

页数：7

共 53 条

[1] Gout - a guide for the general and acute physicians [J].

Abhishek, Abhishek ;

Roddy, Edward ;

Doherty, Michael .

CLINICAL MEDICINE, 2017, 17 (01) :54-59

[2] Crystal-induced neutrophil activation VI.: Involvement of FcγRIIIB (CD16) and CD11b in response to inflammatory microcrystals [J].

Barabé, F ;

Gilbert, C ;

Liao, N ;

Bourgoin, SG ;

Naccache, PH .

FASEB JOURNAL, 1998, 12 (02) :209-220

[3] Integrated Genomics of Crohn's Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy [J].

Begun, Jakob ;

Lassen, Kara G. ;

Jijon, Humberto B. ;

Baxt, Leigh A. ;

Goel, Gautam ;

Heath, Robert J. ;

Ng, Aylwin ;

Tam, Jenny M. ;

Kuo, Szu-Yu ;

Villablanca, Eduardo J. ;

Fagbami, Lola ;

Oosting, Marije ;

Kumar, Vinod ;

Schenone, Monica ;

Carr, Steven A. ;

Joosten, Leo A. B. ;

Vyas, Jatin M. ;

Daly, Mark J. ;

Netea, Mihai G. ;

Brown, Gordon D. ;

Wijmenga, Cisca ;

Xavier, Ramnik J. .

CELL REPORTS, 2015, 11 (12) :1905-1918

[4] Mapping the CLEC12A expression on myeloid progenitors in normal bone marrow; implications for understanding CLEC12A-related cancer stem cell biology [J].

Bill, Marie ;

Niekerk, Peter B. van Kooten ;

Woll, Petter S. ;

Herborg, Laura Laine ;

Roug, Anne Stidsholt ;

Hokland, Peter ;

Nederby, Line .

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2018, 22 (04) :2311-2318

[5] CTLA-4 and PD-1 Pathways Similarities, Differences, and Implications of Their Inhibition [J].

Buchbinder, Elizabeth I. ;

Desai, Anupam .

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 2016, 39 (01) :98-106

[6] Mechanisms of inflammation in gout [J].

Busso, Nathalie ;

So, Alexander .

ARTHRITIS RESEARCH & THERAPY, 2010, 12 (02)

[7] SUPPRESSION OF URATE CRYSTAL-INDUCED CANINE JOINT INFLAMMATION BY HETEROLOGOUS ANTI-POLYMORPHONUCLEAR LEUKOCYTE SERUM [J].

CHANG, YH ;

GRALLA, EJ .

ARTHRITIS AND RHEUMATISM, 1968, 11 (2P1) :145-&

[8] Monosodium Urate Crystals Generate Nuclease-Resistant Neutrophil Extracellular Traps via a Distinct Molecular Pathway [J].

Chatfield, Simon M. ;

Grebe, Kathrin ;

Whitehead, Lachlan W. ;

Rogers, Kelly L. ;

Nebl, Thomas ;

Murphy, James M. ;

Wicks, Ian P. .

JOURNAL OF IMMUNOLOGY, 2018, 200 (05) :1802-1816

[9] Dendritic-cell-associated C-type lectin 2 (DCAL-2) alters dendritic-cell maturation and cytokine production [J].

Chen, CH ;

Floyd, H ;

Olson, NE ;

Magaletti, D ;

Li, C ;

Draves, K ;

Clark, EA .

BLOOD, 2006, 107 (04) :1459-1467

[10] Mechanistic Aspects of Inflammation and Clinical Management of Inflammation in Acute Gouty Arthritis [J].

Cronstein, Bruce N. ;

Sunkureddi, Prashanth .

JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, 2013, 19 (01) :19-29

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