Is biological aging accelerated in drug addiction?

被引：66

作者：

Bachi, Keren ^{[1
,2
]}

Sierra, Salvador ^{[3
]}

Volkow, Nora D. ^{[4
]}

Goldstein, Rita Z. ^{[1
,2
]}

Alia-Klein, Nelly ^{[1
,2
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY 10029 USA

[3] Icahn Sch Med Mt Sinai, Dept Pharmacol & Syst Therapeut, New York, NY 10029 USA

[4] Natl Inst Drug Abuse, Bethesda, MD USA

来源：

CURRENT OPINION IN BEHAVIORAL SCIENCES | 2017年 / 13卷

基金：

美国国家卫生研究院;

关键词：

LEUKOCYTE TELOMERE LENGTH; OXIDATIVE STRESS; MICROGLIAL ACTIVATION; COCAINE DEPENDENCE; PERIPHERAL ORGANS; BRAIN; TOXICITY; DISEASE; ABUSE; AGE;

D O I：

10.1016/j.cobeha.2016.09.007

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Drug-addiction may trigger early onset of age-related disease, due to drug-induced multi-system toxicity and perilous lifestyle, which remains mostly undetected and untreated. We present the literature on pathophysiological processes that may hasten aging and its relevance to addiction, including: oxidative stress and cellular aging, inflammation in periphery and brain, decline in brain volume and function, and early onset of cardiac, cerebrovascular, kidney, and liver disease. Timely detection of accelerated aging in addiction is crucial for the prevention of premature morbidity and mortality.

引用

页码：34 / 39

页数：6

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