A facile synthesis of beta-lactams based on the isocyanide chemistry

被引：75
作者：
Bossio, R [1 ]
Marcos, CF [1 ]
Marcaccini, S [1 ]
Pepino, R [1 ]
机构：
[1] UNIV FLORENCE, CNR, DIPARTIMENTO CHIM ORGAN UGO SCHIFF, I-50121 FLORENCE, ITALY
来源：
TETRAHEDRON LETTERS | 1997年 / 38卷 / 14期
关键词：
D O I：
10.1016/S0040-4039(97)00389-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reaction between (E)-cinnamaldehyde (1), chloroacetic acid (2), cyclohexyl isocyanide (3), and amines 4 afforded the expected Ugi 4-CC products 5, which were easily cyclised to (E)-1-substituted N-cyclohexyl-2-(1-phenylethen-2-yl)-4-oxoazetidine-2-carboxamides 6 upon treatment with methanolic KOH. (C) 1997 Elsevier Science Ltd.
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页码：2519 / 2520
页数：2
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