Self-Nucleic Acid Sensing: A Novel Crucial Pathway Involved in Obesity-Mediated Metaflammation and Metabolic Syndrome

被引:16
作者
Ferriere, Amandine [1 ]
Santa, Pauline [1 ]
Garreau, Anne [1 ]
Bandopadhyay, Purbita [2 ]
Blanco, Patrick [1 ,3 ]
Ganguly, Dipyaman [2 ]
Sisirak, Vanja [1 ]
机构
[1] Bordeaux Univ, CNRS, UMR 5164, Immunoconcept, Bordeaux, France
[2] Indian Inst Chem Biol, CSIR, Div Canc Biol & Inflammatory Disorders, IICB,Translat Res Unit Excellence, Kolkata, India
[3] Bordeaux Univ Hosp, Immunol & Immunogenet Dept, Bordeaux, France
关键词
nucleic acids; obesity; metabolic syndrome; metainflammation; inflammation; nucleic acid sensing; non-alcoholic steatohepatitis;
D O I
10.3389/fimmu.2020.624256
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Obesity and overweight are a global health problem affecting almost one third of the world population. There are multiple complications associated with obesity including metabolic syndrome that commonly lead to development of type II diabetes and non-alcoholic fatty liver disease. The development of metabolic syndrome and severe complications associated with obesity is attributed to the chronic low-grade inflammation that occurs in metabolic tissues such as the liver and the white adipose tissue. In recent years, nucleic acids (mostly DNA), which accumulate systemically in obese individuals, were shown to aberrantly activate innate immune responses and thus to contribute to metabolic tissue inflammation. This minireview will focus on (i) the main sources and forms of nucleic acids that accumulate during obesity, (ii) the sensing pathways required for their detection, and (iii) the key cellular players involved in this process. Fully elucidating the role of nucleic acids in the induction of inflammation induced by obesity would promote the identification of new and long-awaited therapeutic approaches to limit obesity-mediated complications.
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页数:8
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共 74 条
[51]   Hematopoietic Stem Cells Are the Major Source of Multilineage Hematopoiesis in Adult Animals [J].
Sawai, Catherine M. ;
Babovic, Sonja ;
Upadhaya, Samik ;
Knapp, David J. H. F. ;
Lavin, Yonit ;
Lau, Colleen M. ;
Goloborodko, Anton ;
Feng, Jue ;
Fujisaki, Joji ;
Ding, Lei ;
Mirny, Leonid A. ;
Merad, Miriam ;
Eaves, Connie J. ;
Reizis, Boris .
IMMUNITY, 2016, 45 (03) :597-609
[52]   Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes [J].
Schauer, Philip R. ;
Kashyap, Sangeeta R. ;
Wolski, Kathy ;
Brethauer, Stacy A. ;
Kirwan, John P. ;
Pothier, Claire E. ;
Thomas, Susan ;
Abood, Beth ;
Nissen, Steven E. ;
Bhatt, Deepak L. .
NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (17) :1567-1576
[53]   Drug developers switch gears to inhibit STING [J].
Sheridan, Cormac .
NATURE BIOTECHNOLOGY, 2019, 37 (03) :199-201
[54]   Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis [J].
Shimada, Kenichi ;
Crother, Timothy R. ;
Karlin, Justin ;
Dagvadorj, Jargalsaikhan ;
Chiba, Norika ;
Chen, Shuang ;
Ramanujan, V. Krishnan ;
Wolf, Andrea J. ;
Vergnes, Laurent ;
Ojcius, David M. ;
Rentsendorj, Altan ;
Vargas, Mario ;
Guerrero, Candace ;
Wang, Yinsheng ;
Fitzgerald, Katherine A. ;
Underhill, David M. ;
Town, Terrence ;
Arditi, Moshe .
IMMUNITY, 2012, 36 (03) :401-414
[55]   Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity [J].
Sisirak, Vanja ;
Sally, Benjamin ;
D'Agati, Vivette ;
Martinez-Ortiz, Wilnelly ;
Ozcakar, Z. Birsin ;
David, Joseph ;
Rashidfarrokhi, Ali ;
Yeste, Ada ;
Panea, Casandra ;
Chida, Asiya Seema ;
Bogunovic, Milena ;
Ivanov, Ivaylo I. ;
Quintana, Francisco J. ;
Sanz, Inaki ;
Elkon, Keith B. ;
Tekin, Mustafa ;
Yalcinkaya, Fatos ;
Cardozo, Timothy J. ;
Clancy, Robert M. ;
Buyon, Jill P. ;
Reizis, Boris .
CELL, 2016, 166 (01) :88-101
[56]   Plasmacytoid Dendritic Cells and Type I Interferon Promote Extrafollicular B Cell Responses to Extracellular Self-DNA [J].
Soni, Chetna ;
Perez, Oriana A. ;
Voss, William N. ;
Pucella, Joseph N. ;
Serpas, Lee ;
Mehl, Justin ;
Ching, Krystal L. ;
Goike, Jule ;
Georgiou, George ;
Ippolito, Gregory C. ;
Sisirak, Vanja ;
Reizis, Boris .
IMMUNITY, 2020, 52 (06) :1022-+
[57]   Dendritic cells promote macrophage infiltration and comprise a substantial proportion of obesity-associated increases in CD11c+ cells in adipose tissue and liver [J].
Stefanovic-Racic, Maja ;
Yang, Xiao ;
Turner, Michael S. ;
Mantell, Benjamin S. ;
Stolz, Donna B. ;
Sumpter, Tina L. ;
Sipula, Ian J. ;
Dedousis, Nikolaos ;
Scott, Donald K. ;
Morel, Penelope A. ;
Thomson, Angus W. ;
O'Doherty, Robert M. .
DIABETES, 2012, 61 (09) :2330-2339
[58]   The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity [J].
Stienstra, Rinke ;
Joosten, Leo A. B. ;
Koenen, Tim ;
van Tits, Berry ;
van Diepen, Janna A. ;
van den Berg, Sjoerd A. A. ;
Rensen, Patrick C. N. ;
Voshol, Peter J. ;
Fantuzzi, Giamilla ;
Hijmans, Anneke ;
Kersten, Sander ;
Muller, Michael ;
van den Berg, Wim B. ;
van Rooijen, Nico ;
Wabitsch, Martin ;
Kullberg, Bart-Jan ;
van der Meer, Jos W. M. ;
Kanneganti, Thirumala ;
Tack, Cees J. ;
Netea, Mihai G. .
CELL METABOLISM, 2010, 12 (06) :593-605
[59]   Adipocyte death, adipose tissue remodeling, and obesity complications [J].
Strissel, Katherine J. ;
Stancheva, Zlatina ;
Miyoshi, Hideaki ;
Perfield, James W., II ;
DeFuria, Jason ;
Jick, Zoe ;
Greenberg, Andrew S. ;
Obin, Martin S. .
DIABETES, 2007, 56 (12) :2910-2918
[60]   Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE [J].
Tian, Jane ;
Avalos, Ana Maria ;
Mao, Su-Yau ;
Chen, Bo ;
Senthil, Kannaki ;
Wu, Herren ;
Parroche, Peggy ;
Drabic, Stacey ;
Golenbock, Douglas ;
Sirois, Cherilyn ;
Hua, Jing ;
An, Ling Ling ;
Audoly, Laurent ;
La Rosa, Greg ;
Bierhaus, Angelika ;
Naworth, Peter ;
Marshak-Rothstein, Ann ;
Crow, Mary K. ;
Fitzgerald, Katherine A. ;
Latz, Eicke ;
Kiener, Peter A. ;
Coyle, Anthony J. .
NATURE IMMUNOLOGY, 2007, 8 (05) :487-496