Epstein-Barr virus-infected malignant T/NK-cell lymphoma in a patient with hypersensitivity to mosquito bites

被引：4

作者：

Kase, S

Adachi, H

Osaki, M

Murakami, M

Sairenji, T

Hashimoto, K

Teramoto, H

Yamamoto, S

Makino, H

Shimizu, E

Watanabe, T

Ohsawa, T

Hagari, Y

Mihara, M

Ito, H

机构：

[1] Tottori Univ, Fac Med, Dept Pathol & Microbiol, Div Organ Pathol, Yonago, Tottori 6838503, Japan

[2] Tottori Univ, Grad Sch Med, Dept Biomed Sci, Div Mol Genet & Biofunct, Yonago, Tottori 6838503, Japan

[3] Tottori Univ, Fac Med, Dept Biomed Sci, Div Biosignaling, Yonago, Tottori 6838503, Japan

[4] Tottori Univ, Fac Med, Dept Multidisciplinary Internal Med, Div Internal Med & Mol Therapeut, Yonago, Tottori 6838503, Japan

[5] Tottori Univ, Fac Med, Dept Med Sensory & Motor Organs, Div Dermatol, Yonago, Tottori 6838503, Japan

来源：

INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY | 2004年 / 12卷 / 03期

关键词：

Epstein-Barr virus; hypersensitivity to mosquito bites; Ki-67; lymphoma;

D O I：

10.1177/106689690401200310

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

We report an autopsy case of Epstein-Barr virus (EBV)-infected malignant lymphoma in a young male who had hypersensitivity to mosquito bites. The autopsy revealed multiple confluent lymphoma lesions in the lungs, and on the right leg irregular-shaped skin ulcers were seen. The left pleural effusion also contained a large number of lymphoma cells. The lymphoma cells were determined as T/NK-cell type cells by immunohistochemistry. EBV DNA was detected most intensively in the lungs and EBV-encoded small RNAs-positive lymphoma cells were also observed in the lungs at a high frequency. EBV latent membrane protein-1 expression and a high Ki-67 labeling indices were noted in the lymphoma cells of the lung lesions. These findings indicate that the development of the malignant lymphoma was associated with the proliferation of EBV-infected lymphoma cells, and the cells that infiltrated the whole the body, especially the lungs, caused the patient's death.

引用

页码：265 / 272

页数：8