Striatal Dopamine and Reward Prediction Error Signaling in Unmedicated Schizophrenia Patients

被引:43
|
作者
Katthagen, Teresa [1 ,2 ,3 ,4 ]
Kaminski, Jakob [1 ,2 ,3 ,4 ,5 ]
Heinz, Andreas [1 ,2 ,3 ,4 ,6 ]
Buchert, Ralph [7 ]
Schlagenhauf, Florian [1 ,2 ,3 ,4 ,5 ,8 ]
机构
[1] Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Charite Campus Mitte,Charitepl 1, D-10117 Berlin, Germany
[2] Free Univ Berlin, Berlin, Germany
[3] Humboldt Univ, Berlin, Germany
[4] Berlin Inst Hlth, Berlin, Germany
[5] Max Planck Inst Human Cognit & Brain Sci, Leipzig, Germany
[6] Charite, Cluster Excellence NeuroCure, Berlin, Germany
[7] Univ Med Ctr Hamburg Eppendorf, Dept Diagnost & Intervent Radiol & Nucl Med, Hamburg, Germany
[8] Bernstein Ctr Computat Neurosci, Berlin, Germany
关键词
psychosis; reinforcement learning; computational psychiatry; PET; reversal learning; fMRI; POSITRON-EMISSION-TOMOGRAPHY; NEGATIVE SYNDROME SCALE; SYNTHESIS CAPACITY; MOTIVATIONAL DEFICITS; ABERRANT SALIENCE; LEARNING SIGNALS; SUBSTANCE USE; PSYCHOSIS; BRAIN; DYSFUNCTION;
D O I
10.1093/schbul/sbaa055
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Increased striatal dopamine synthesis capacity has consistently been reported in patients with schizophrenia. However, the mechanism translating this into behavior and symptoms remains unclear. It has been proposed that heightened striatal dopamine may blunt dopaminergic reward prediction error signaling during reinforcement learning. In this study, we investigated striatal dopamine synthesis capacity, reward prediction errors, and their association in unmedicated schizophrenia patients (n = 19) and healthy controls (n = 23). They took part in FDOPA-PET and underwent functional magnetic resonance imaging (fMRI) scanning, where they performed a reversal-learning paradigm. The groups were compared regarding dopamine synthesis capacity (Ki(cer)), fMRI neural prediction error signals, and the correlation of both. Patients did not differ from controls with respect to striatal Ki(cer). Taking into account, comorbid alcohol abuse revealed that patients without such abuse showed elevated Ki(cer) in the associative striatum, while those with abuse did not differ from controls. Comparing all patients to controls, patients performed worse during reversal learning and displayed reduced prediction error signaling in the ventral striatum. In controls, Ki(cer) in the limbic striatum correlated with higher reward prediction error signaling, while there was no significant association in patients. Ki(cer) in the associative striatum correlated with higher positive symptoms and blunted reward prediction error signaling was associated with negative symptoms. Our results suggest a dissociation between striatal subregions and symptom domains, with elevated dopamine synthesis capacity in the associative striatum contributing to positive symptoms while blunted prediction error signaling in the ventral striatum related to negative symptoms.
引用
收藏
页码:1535 / 1546
页数:12
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