Mammary development meets cancer genomics

被引：146

作者：

Prat, Aleix ^{[1
,2
]}

Perou, Charles M. ^{[1
,2
]}

机构：

[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Genet, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Pathol & Lab Med, Chapel Hill, NC 27599 USA

来源：

NATURE MEDICINE | 2009年 / 15卷 / 08期

关键词：

INVASIVE BREAST-CARCINOMA; BASAL-LIKE SUBTYPE; MOLECULAR PORTRAITS; STEM-CELLS; TUMORS;

D O I：

10.1038/nm0809-842

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mammary epithelial cell development is thought to progress from undifferentiated stem cells into at least two differentiated cell types. A new study has now characterized some of these distinct developmental stages and links them to tumor subtypes previously defined by gene expression profiling (pages 907-913).

引用

页码：842 / 844

页数：4

共 17 条

[1] The triple negative paradox: Primary tumor chemosensitivity of breast cancer subtypes [J].

Carey, Lisa A. ;

Dees, E. Claire ;

Sawyer, Lynda ;

Gatti, Lisa ;

Moore, Dominic T. ;

Collichio, Frances ;

Ollila, David W. ;

Sartor, Carolyn I. ;

Graham, Mark L. ;

Perou, Charles M. .

CLINICAL CANCER RESEARCH, 2007, 13 (08) :2329-2334

[2] Molecular portraits and the family tree of cancer [J].

Chung, CH ;

Bernard, PS ;

Perou, CM .

NATURE GENETICS, 2002, 32 (Suppl 4) :533-540

[3]

CREIGHTON C, P NAT ACAD IN PRESS

[4] Circulating tumor cells, disease progression, and survival in metastatic breast cancer [J].

Cristofanilli, M ;

Budd, GT ;

Ellis, MJ ;

Stopeck, A ;

Matera, J ;

Miller, MC ;

Reuben, JM ;

Doyle, GV ;

Allard, WJ ;

Terstappen, LWMM ;

Hayes, DF .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (08) :781-791

[5] Association of reactive oxygen species levels and radioresistance in cancer stem cells [J].

Diehn, Maximilian ;

Cho, Robert W. ;

Lobo, Neethan A. ;

Kalisky, Tomer ;

Dorie, Mary Jo ;

Kulp, Angela N. ;

Qian, Dalong ;

Lam, Jessica S. ;

Ailles, Laurie E. ;

Wong, Manzhi ;

Joshua, Benzion ;

Kaplan, Michael J. ;

Wapnir, Irene ;

Dirbas, Frederick M. ;

Somlo, George ;

Garberoglio, Carlos ;

Paz, Benjamin ;

Shen, Jeannie ;

Lau, Sean K. ;

Quake, Stephen R. ;

Brown, J. Martin ;

Weissman, Irving L. ;

Clarke, Michael F. .

NATURE, 2009, 458 (7239) :780-U123

[6] BRCA1 functions as a breast stem cell regulator [J].

Foulkes, WD .

JOURNAL OF MEDICAL GENETICS, 2004, 41 (01) :1-5

[7] ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome [J].

Ginestier, Christophe ;

Hur, Min Hee ;

Charafe-Jauffret, Emmanuelle ;

Monville, Florence ;

Dutcher, Julie ;

Brown, Marty ;

Jacquemier, Jocelyne ;

Viens, Patrice ;

Kleer, Celina G. ;

Liu, Suling ;

Schott, Anne ;

Hayes, Dan ;

Birnbaum, Daniel ;

Wicha, Max S. ;

Dontu, Gabriela .

CELL STEM CELL, 2007, 1 (05) :555-567

[8] Characterization of a Naturally Occurring Breast Cancer Subset Enriched in Epithelial-to-Mesenchymal Transition and Stem Cell Characteristics [J].

Hennessy, Bryan T. ;

Gonzalez-Angulo, Ana-Maria ;

Stemke-Hale, Katherine ;

Gilcrease, Michael Z. ;

Krishnamurthy, Savitri ;

Lee, Ju-Seog ;

Fridlyand, Jane ;

Sahin, Aysegul ;

Agarwal, Roshan ;

Joy, Corwin ;

Liu, Wenbin ;

Stivers, David ;

Baggerly, Keith ;

Carey, Mark ;

Lluch, Ana ;

Monteagudo, Carlos ;

He, Xiaping ;

Weigman, Victor ;

Fan, Cheng ;

Palazzo, Juan ;

Hortobagyi, Gabriel N. ;

Nolden, Laura K. ;

Wang, Nicholas J. ;

Valero, Vicente ;

Gray, Joe W. ;

Perou, Charles M. ;

Mills, Gordon B. .

CANCER RESEARCH, 2009, 69 (10) :4116-4124

[9] Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors [J].

Herschkowitz, Jason I. ;

Simin, Karl ;

Weigman, Victor J. ;

Mikaelian, Igor ;

Usary, Jerry ;

Hu, Zhiyuan ;

Rasmussen, Karen E. ;

Jones, Laundette P. ;

Assefnia, Shahin ;

Chandrasekharan, Subhashini ;

Backlund, Michael G. ;

Yin, Yuzhi ;

Khramtsov, Andrey I. ;

Bastein, Roy ;

Quackenbush, John ;

Glazer, Robert I. ;

Brown, Powel H. ;

Green, Jeffrey E. ;

Kopelovich, Levy ;

Furth, Priscilla A. ;

Palazzo, Juan P. ;

Olopade, Olufunmilayo I. ;

Bernard, Philip S. ;

Churchill, Gary A. ;

Van Dyke, Terry ;

Perou, Charles M. .

GENOME BIOLOGY, 2007, 8 (05)

[10] Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy [J].

Li, Xiaoxian ;

Lewis, Michael T. ;

Huang, Jian ;

Gutierrez, Carolina ;

Osborne, C. Kent ;

Wu, Meng-Fen ;

Hilsenbeck, Susan G. ;

Pavlick, Anne ;

Zhang, Xiaomei ;

Chamness, Gary C. ;

Wong, Helen ;

Rosen, Jeffrey ;

Chang, Jenny C. .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2008, 100 (09) :672-679

← 1 2 →