Unusual alkylation reactions in the biosynthesis of natural products and elucidation of their reaction mechanisms

被引：0

作者：

Glasenapp-Breiling, M ^{[1
]}

Montforts, FP ^{[1
]}

机构：

[1] Univ Bremen, Inst Organ Chem, FB Biol Chem 2, D-28334 Bremen, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2000年 / 39卷 / 04期

关键词：

biosynthesis; cobalamins; methylations; radicals; radical reactions;

D O I：

10.1002/(SICI)1521-3773(20000218)39:4<721::AID-ANIE721>3.0.CO;2-Y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Methylcorrinoids as methylation coenzymes in radical C-methylations: Unusual alkylation reactions at nonactivated carbon atoms of natural products can be explained for the first time by a unique reaction of methylcobalamin (1). According to the mechanistic course of the reaction the corrin part of the vitamin B12 derivative 1 undergoes substitution at the methyl group by carbon radicals with inversion of configuration.

引用

页码：721 / +

页数：4

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