A Supramolecular Polymer as a Self-Assembling Polyvalent Scaffold

被引：111
|
作者：
Mueller, Marion K. [2 ,3 ]
Brunsveld, Luc [1 ,2 ,3 ]
机构：
[1] TU Eindhoven, Dept Biomed Engn, Biol Chem Lab, Eindhoven, Netherlands
[2] Max Planck Inst Mol Physiol, Dept Biol Chem, D-44227 Dortmund, Germany
[3] Chem Genom Ctr, D-44227 Dortmund, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 16期
关键词：
carbohydrates; fluorescence; polyvalency; self-assembly; supramolecular polymers; CONCANAVALIN-A; TERMINAL ALKYNES; BINDING; LIGANDS; LECTIN; AZIDES; THERMODYNAMICS; AMPLIFICATION; GALECTIN-1; NANOFIBERS;
D O I：
10.1002/anie.200900143
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Binding bacteria: Discotic molecules self-assemble into columnar supramolecular polymers that show strong polyvalent binding to bacteria by virtue of mannose ligands attached at their periphery (orange; see picture). The reversible formation of the supramolecular polymers allows simple mixing of differently substituted monomers and the optimization of bacterial aggregation. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：2921 / 2924
页数：4
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