Melatonin: Pharmacology, Functions and Therapeutic Benefits

被引:578
作者
Tordjman, Sylvie [1 ,2 ]
Chokron, Sylvie [2 ]
Delorme, Richard [3 ]
Charrier, Annaelle [1 ]
Bellissant, Eric [4 ,5 ]
Jaafari, Nemat [6 ,7 ]
Fougerou, Claire [4 ,5 ]
机构
[1] Univ Rennes 1, Dept Child & Adolescent Psychiat, Guillaume Regnier Hosp, Univ Hosp, F-35000 Rennes, France
[2] CNRS UMR 8158, Lab Psychol Percept, F-75270 Paris, France
[3] Paris 7 Univ, Robert Debre Hosp, Child & Adolescent Psychiat Dept, F-75019 Paris, France
[4] Univ Rennes 1, Univ Hosp, Inserm CIC 1414, Clin Invest Ctr, F-35033 Rennes, France
[5] Univ Rennes 1, Univ Hosp, Dept Clin Pharmacol, F-35033 Rennes, France
[6] Ctr Hosp Henri Laborit, INSERM CIC P 1402, Unite Rech Clin Pierre Deniker, F-86034 Poitiers, France
[7] Univ Poitiers, INSERM U 1084, Lab Expt & Clin Neurosci, F-86022 Poitiers, France
关键词
Adaptation to external and internal environment; biological clocks; biomarker; clinical application; central and peripheral oscillators; melatonin; prevention and treatment; sleep-wake rhythm; synchronizer; CEREBRAL-ARTERY OCCLUSION; RHYTHM SLEEP DISORDERS; PRETERM INFANTS; PINEAL-GLAND; COLON CARCINOGENESIS; N-ACETYLTRANSFERASE; EXPRESSION CLONING; CIRCADIAN-RHYTHMS; OXIDATIVE STRESS; SERUM MELATONIN;
D O I
10.2174/1570159X14666161228122115
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Melatonin synchronizes central but also peripheral oscillators (fetal adrenal gland, pancreas, liver, kidney, heart, lung, fat, gut, etc.), allowing temporal organization of biological functions through circadian rhythms (24-hour cycles) in relation to periodic environmental changes and therefore adaptation of the individual to his/her internal and external environment. Measures of melatonin are considered the best peripheral indices of human circadian timing based on an internal 24-hour clock. Methods: First, the pharmacology of melatonin (biosynthesis and circadian rhythms, pharmacokinetics and mechanisms of action) is described, allowing a better understanding of the short and long term effects of melatonin following its immediate or prolonged release. Then, research related to the physiological effects of melatonin is reviewed. Results: The physiological effects of melatonin are various and include detoxification of free radicals and antioxidant actions, bone formation and protection, reproduction, and cardiovascular, immune or body mass regulation. Also, protective and therapeutic effects of melatonin are reported, especially with regard to brain or gastrointestinal protection, psychiatric disorders, cardiovascular diseases and oncostatic effects. Conclusion: This review highlights the high number and diversity of major melatonin effects and opens important perspectives for measuring melatonin as a biomarker (biomarker of early identification of certain disorders and also biomarker of their follow-up) and using melatonin with clinical preventive and therapeutic applications in newborns, children and adults based on its physiological regulatory effects.
引用
收藏
页码:434 / 443
页数:10
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